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Table 3 Hazard ratios of total hip replacement for osteoarthritis in relation to circulating 25-hydroxyvitamin D concentrations

From: Association between circulating 25-hydroxyvitamin D concentrations and hip replacement for osteoarthritis: a prospective cohort study

 

Model 1a, HR (95% CI)

Model 2b, HR (95% CI)

Men

 25(OH)D (per 25 nmol/L increment)

1.23 (0.95-1.60) p = 0.12

1.26 (0.95-1.67) p = 0.11

25(OH)D Quartiles

 1 (<43.00 nmol/L)

Reference

Reference

 2 (43.00 to <54.85 nmol/L)

2.06 (1.02-4.13)

2.32 (1.05-5.13)

 3 (54.85 to <69.22 nmol/L)

2.40 (1.21-4.75)

2.77 (1.28-6.00)

 4 (≥69.22 nmol/L)

1.57 (0.75-3.29)

1.73 (0.75-4.02)

P for trend

0.04

0.02

Women

 25(OH)D (per 25 nmol/L increment)

0.97 (0.64-1.47) p = 0.90

0.94 (0.60-1.47) p = 0.78

25(OH)D Quartiles

 1 (<34.8 nmol/L)

Reference

Reference

 2 (34.8 to <42.92 nmol/L)

0.74 (0.40-1.37)

0.60 (0.32-1.16)

 3 (42.92 to <53.04 nmol/L)

0.92 (0.51-1.66)

0.79 (0.43-1.47)

 4 (≥53.04 nmol/L)

0.86 (0.47-1.57)

0.77 (0.41-1.44)

P for trend

0.93

0.34

  1. 25(OH)D 25-hydroxyvitamin D, HR hazard ratio, CI confidence interval
  2. aadjusted for BMI, vigorous physical activity, smoking status, country of birth, and SEIFA
  3. badjusted for BMI, vigorous physical activity, smoking status, country of birth, SEIFA, and co-morbidities (diabetes and hypertension)