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Fig. 6. | BMC Musculoskeletal Disorders

Fig. 6.

From: Experimental study of the effects of hypoxia simulator on osteointegration of titanium prosthesis in osteoporotic rats

Fig. 6.

Sections of new bone tissue around the implants were examined by immunohistochemistry 2 weeks after surgery. A A representative photomicrograph showed there were more HIF-1a, VEGF, and CD31 positive cells in the DFO group than in the control group. The CD31 was expressed clearly in clusters, which indicated that there was more neovascularization. Only a small amount of HIF-2a was expressed in both groups. The appearance of a brown substance (black arrows) indicats antigen-positive staining (original magnification: 200 × per image, scale bars represent 20 μm). B Bar graphs showing the mean optical density of HIF-1a, VEGF, and CD31 in bone tissue. Semiquantitative analysis was performed for eight sections (10 fields per section) in each group, and the difference was obvious. There was no difference in HIF-2a expression between the two groups. An asterisk (*) indicates p < 0.05

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