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Table 1 Comprehensive summery of all outcome parameters with subgroup analysis AKA versus LS

From: Risk factor analysis for above-knee amputation in patients with periprosthetic joint infection of the knee: a case-control study

 

all patients (n = 68)

AKA (n = 11)

LS (n = 57)

P

n (%)

mean ±

n (%)

mean ±

n (%)

mean ±

DEMOGRAPHICS

Gender

 Female

37 (54)

 

6 (56)

 

31 (54)

 

0.992

 Male

31 (46)

 

5 (45)

 

26 (46)

 

Patient age at index surgery

 

71.0 ± 11.2

 

67.4 ± 14.3

 

71.7 ± 10.5

0.249

BMI (kg/m2)

 

30.6 ± 8.2

 

29.5 ± 11.5

 

30.8 ± 7.5

0.619

Smoker

16 (24)

 

5 (45)

 

11 (19)

 

0.061

Alcohol abuse

3 (4)

 

2 (18)

 

1 (2)

 

0.015

ASA

 1

0 (0)

 

0 (0)

 

0 (0)

 

0.009

 2

27 (40)

 

1 (9)

 

26 (46)

 

 3

36 (53)

 

10 (91)

 

26 (46)

 

 4

5 (7)

 

0 (0)

 

5 (9)

 

Charlson Score ≥ 3

13 (19)

 

4 (36)

 

9 (16)

 

0.112

DISEASE RELATED FACTORS

Type of infection

 Acute/early

47 (69)

 

9 (82)

 

38 (67)

 

0.439

 Chronic/delayed

18 (26)

 

2 (18)

 

16 (28)

 

 Unknown

3 (4)

 

0 (0)

 

3 (5)

  

Joint fistula present

11 (16)

 

1 (9)

 

10 (18)

 

0.486

Anemiaa

44 (65)

 

11 (100)

 

33 (58)

 

0.022

Hemoglobin (g/dl)

 

115 ± 21

 

98 ± 15

 

118 ± 20

0.011

CRP (mg/l)

 

130 ± 113

 

119 ± 106

 

132 ± 115

0.736

WBC (n ×  109/l)

 

10 ± 4

 

9 ± 3

 

11 ± 5

0.355

Positive blood cultures

18 (26)

 

4 (36)

 

12 (21)

 

0.273

Joint aspirate: leucocyte cell count (n/mm3)b

 

32,920 ± 33,028

 

68,030 ± 11,652

 

21,230 ± 16,329

0.404

Microbiology:

 Monomicrobial

41 (60)

 

7 (64)

 

34 (60)

 

0.976

 Polymicrobial

19 (28)

 

4 (36)

 

15 (26)

 

0.497

 Culture negative

6 (9)

 

0 (0)

 

6 (11)

 

0.260

 Incomplete records

2 (3)

 

0 (0)

 

2 (4)

  

Resistance pattern

 Pansensitive

35 (51)

 

4 (36)

 

31 (54)

 

0.148

 Resistances present

10 (15)

 

1 (9)

 

20 (35)

 

 Multiresistent

23 (34)

 

6 (56)

 

17 (30)

 

IMPLANT/PREVIOUS SURGERY RELATED FACTORS

Knee surgery prior to KA

17 (25)

 

3 (27)

 

14 (25)

 

0.849

Patient age at KA implantation

 

67.2 ± 11.3

 

63.6 ± 15.2

 

67.9 ± 10.5

0.249

Primary implantation elsewhere

15 (22)

 

3 (27)

 

12 (21)

 

0.649

Type of implant

 Unicompartimental

1 (1)

 

0 (0)

 

1 (2)

 

0.658

 PS/CR

53 (78)

 

7 (64)

 

46 (81)

 

0.211

 Hinged

11 (16)

 

3 (27)

 

8 (14)

 

0.275

 Megaprosthesis

3 (4)

 

1 (9)

 

2 (4)

 

0.409

Revision prosthesis

14 (21)

 

3 (27)

 

11 (19)

 

0.549

TREATMENT RELATED FACTORS

Previous intervention elsewhere

22 (32)

 

5 (45)

 

17 (30)

 

0.310

Blood transfusion

23 (34)

 

6 (56)

 

17 (30)

 

0.122

  1. aThe world health organization identifies anemia as hemoglobin thresholds of 12.0 g/dl for non-pregnant women and 13.0 g/dl for men
  2. bJoint aspiration was carried out in 62 cases
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