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Fig. 2 | BMC Musculoskeletal Disorders

Fig. 2

From: Defining matrix Gla protein expression in the Dunkin-Hartley guinea pig model of spontaneous osteoarthritis

Fig. 2

Comparison of changes across month-age groups in the DH guinea pig spontaneous osteoarthritis model. A Weight changes with aging. The weight of the DH guinea pigs shows a generally escalating trend with increasing month-age. The month-to-month change is statistically significant where noted. B Modified Mankin Scores (MMS) of knee cartilages in every group. MMS tests show significant month-by-month increases with age in the DH guinea pigs. C In IHC analysis, MGP IOD values in every month-age. There is also a general trend of monthly increase of MGP expression in the joint in the aging DH guinea pigs. D The correlation analysis of MMS and MGP IOD of IHC analysis. The analysis confirms a significant positive correlation between MGP expression and OA severity (as MMS). *The same letter between different groups represented no significant difference

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BMC Musculoskeletal Disorders

ISSN: 1471-2474

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