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Fig. 4 | BMC Musculoskeletal Disorders

Fig. 4

From: Rolipram plays an anti-fibrotic effect in ligamentum flavum fibroblasts by inhibiting the activation of ERK1/2

Fig. 4

Rolipram blocks TGF-β1-induced LF fibroblast fibrosis. (A) a and b, Picture of fibroblasts (40x). c and d, staining with Sirius Red makes the fibroblasts easy to observe (100x). (B) Cell scratch test in LF fibroblasts (100×). (C-G) After fibroblasts were stimulated by TGF-β1 and treated with Rolipram, the expression of Col I, Col3A1, FN1, α-SMA and TGF-β1. GAPDH or β-tubulin served as an endogenous loading control. *p < 0.05, **p < 0.01, ***p < 0.001

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BMC Musculoskeletal Disorders

ISSN: 1471-2474

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