Table 1 Characteristics at baseline
Variables | PRP (n = 20) | Plasma (n = 21) | Placebo (n = 21) |
|---|---|---|---|
Age in years, mean (SD) | 66.4 ± 5.6 | 66.1 ± 7.5 | 62.5 ± 8.1 |
Sex, n (%) | |||
 Male | 1 (5%) | 2 (10%) | 2 (10%) |
 Female | 19 (95%) | 19 (90%) | 19 (90%) |
BMI, mean (SD) | 28.3 ± 4.1 | 28 ± 3.1 | 27.6 ± 3.8 |
BMI – category, n (%) | |||
 < 25 | 6 (30%) | 4 (19%) | 4 (19%) |
 25-30 | 5 (25%) | 11 (52%) | 11 (52%) |
 30-35 | 9 (45%) | 6 (29%) | 6 (29%) |
Knee, n (%) | |||
 Left | 9 (45%) | 9 (43%) | 11 (52%) |
 Right | 11 (55%) | 12 (57%) | 10 (48%) |
X-ray, n (%) | |||
 KL2 | 13 (65%) | 13 (62%) | 14 (67%) |
 KL3 | 7 (35%) | 8 (38%) | 7 (33%) |
Physical Activity, n (%) | 0 (0%) | 0 (0%) | 1 (6%) |
 No | 12 (60%) | 9 (43%) | 9 (43%) |
 Yes | 8 (40%) | 12 (57%) | 12 (57%) |
Comorbidities, n (%) | |||
 No | 4 (20%) | 5 (24%) | 3 (14%) |
 Yes | 16 (80%) | 16 (76%) | 18 (86%) |
Duration of symptoms in years, mean (SD) | 8.4 ± 6.5 | 7 ± 8.1 | 7.1 ± 6.9 |
VAS 0-10 cm for pain, mean (SD) | |||
 Overall | 6.1 ± 1.6 | 5.9 ± 1.4 | 6.6 ± 1.4 |
 At rest | 2.5 ± 2.3 | 1.5 ± 1.9 | 1.9 ± 1.9 |
 At movement | 6.8 ± 2.1 | 6.8 ± 2.1 | 6.8 ± 2 |
PhGA 0-10 cm, mean (SD) | 4.6 ± 1.9 | 4.6 ± 1.5 | 4.1 ± 1.7 |
WOMACa, mean (SD) | |||
 Pain 0-20 | 10.7 ± 3.2 | 9.2 ± 2.5 | 11 ± 3.1 |
 Stiffness 0-8 | 4.4 ± 1.7 | 4 ± 1.4 | 4.3 ± 1.8 |
 Function 0-68 | 37.9 ± 11.6 | 33.5 ± 11.2 | 37 ± 12 |
 Total 0-96 | 52.9 ± 15.5 | 46.7 ± 14.3 | 52.3 ± 15.9 |
KOOS 0-100b, mean (SD) | |||
 Symptoms | 46.1 ± 21 | 56.1 ± 21.6 | 45.4 ± 15.9 |
 Pain | 42.9 ± 15.3 | 50.8 ± 17.5 | 40.7 ± 14.6 |
 ADL | 44.4 ± 15.3 | 51.8 ± 18.6 | 45.4 ± 16.2 |
 Sport/Recreation | 12.8 ± 10.9 | 29.8 ± 21 | 17.4 ± 12.2 |
 QOL | 18.1 ± 13.9 | 29.5 ± 16.4 | 25 ± 15.3 |
TUGT (s), mean (SD) | 13.6 ± 2.8 | 13.8 ± 3.1 | 13.6 ± 3 |
US – synovitis, n (%) | |||
 No | 6 (30%) | 2 (10%) | 1 (5%) |
 GS1 | 8 (40%) | 6 (29%) | 2 (10%) |
 GS2 | 4 (20%) | 5 (24%) | 7 (33%) |
 GS3 | 2 (10%) | 8 (38%) | 11 (52%) |
US - power doppler, n (%) | |||
 No | 16 (80%) | 17 (81%) | 18 (86%) |
 Grade 1 | 1 (5%) | 3 (14%) | 3 (14%) |
 Grade 2 | 3 (15%) | 1 (5%) | 0 (0%) |
US – effusion, n (%) | |||
 No | 6 (30%) | 2 (10%) | 3 (14%) |
 0-2mm | 2 (10%) | 3 (14%) | 1 (5%) |
 2-4mm | 5 (25%) | 6 (29%) | 5 (24%) |
 4-6mm | 4 (20%) | 3 (14%) | 6 (29%) |
 > 6mm | 3 (15%) | 7 (33%) | 6 (29%) |
US – cartilagec, n (%) | |||
 1 | 0 (0%) | 3 (14%) | 1 (5%) |
 2A | 13 (65%) | 8 (38%) | 13 (62%) |
 2B | 3 (15%) | 8 (38%) | 4 (19%) |
 3 | 4 (20%) | 2 (10%) | 3 (14%) |