Table 1 The inclusion and exclusion criteria adopted for selecting the 98 enrolled patients [8]

Inclusion criteria

 Individuals of both genders aged between 50 and 75 with knee osteoarthritis according to the American College of Rheumatology (ACR) criteria

 At least five-year schooling to be able to give written informed consent properly

 Kellgren-Lawrence (KL) knee OA severity grade: between 1 and 4 [ 9]

 Current pain that has persisted for at least two months

 Body Mass Index (BMI) at screening ≤40 kg/m [2]

Exclusion criteria

 Abuse of alcohol or drugs

 Pregnancy or breastfeeding

 Patients who underwent repeated infiltrative therapies suspended from less than three months

 Ongoing treatment with systemic anticoagulants or steroids, or therapy suspended for less than one month

 Hypersensitivity to the study products, previous bone fractures, severe knee trauma, joint deformities, rheumatoid arthritis, inflammatory diseases of joints, other current severe diseases, previous surgical procedures (e.g., meniscectomy, scope debridement)

 Haematological diseases or local skin lesions in the site of treatment inoculation