Fig. 4

Decision curve analysis for nomogram Δ24 compared nomogram 0 predicted the radiological progression of OA. The Y axis shows the net benefit. The x axis of DCA is the threshold of the predicted probability using the nomogram to classify subjects with radiographic progression and subjects without radiographic progression. The gray line represents the hypothesis that all subjects had OA radiological progression; the black line represents the hypothesis that none of the subjects had any radiological progression of OA. The net benefit of using the nomogram Δ24 (blue line) for clinical decision-making exceeds that of using nomogram 0 (red line) across the range of reasonable risk thresholds