Table 4 HOAMS (semi-quantitative MRI) outcomes: Changes over 12 months. Values are number (%), unless otherwise indicated
MRI feature/category | Arthroscopy N = 42 | PHT N = 43 | Difference, % (95% CI) | P-value |
|---|---|---|---|---|
Cartilage | ||||
 Change across all regions (excluding within-grade change): | ||||
  No change | 29 (69%) | 43 (100%) |  | 0.0002a |
  Worsening in 1 subregion | 11 (26%) | 0 |  |  |
  Worsening in 2 subregions | 2 (5%) | 0 |  |  |
  Any worsening | 13 (31) | 0 | 31 (15–47) |  |
 Change across all regions (including within-grade change): | ||||
  Improvement in 1 subregion+ worsening in 1 subregion | 1 (2%) | 0 |  |  |
  No change | 26 (62%) | 41 (95%) |  |  |
  Worsening in 1 subregion only | 11 (26%) | 2 (5%) |  |  |
  Worsening in 2 subregions only | 3 (7%) | 0 |  |  |
  Worsening in 3+ subregions only | 1 (2%) | 0 |  |  |
  Any worsening | 16 (38%) | 2 (5%) | 33 (15–52) | 0.0002b |
BML | ||||
 Change in no. of subregions affected by any lesion: | ||||
  Improvement | 1 (2%) | 1 (2%) |  | 0.61a |
  No change | 38 (91%) | 40 (93%) |  |  |
  Worsening in 1 subregion | 1 (2%) | 2 (5%) |  |  |
  Worsening in 2 subregions | 2 (5%) | 0 |  |  |
 Maximum change in BML score across all subregions: | ||||
  No changec | 37 (88%) | 40 (93%) |  | 0.66a |
  Within-grade worsening | 2 (5%) | 0 |  |  |
  Worsening by 1 grade | 3 (7%) | 3 (7%) |  |  |
  Any subregion with improvement (including within-grade changes) in BML | 2 (5%) | 4 (9%) | −4 (−18–9) |  |
  Any subregion with worsening (including within-grade changes) in BML | 5 (12%) | 3 (7%) | 5 (−10–20) |  |
 Subchondral cyst | ||||
 Change in no. of subregions affected: | ||||
  Improvement | 5 (12%) | 0 |  | 0.11a |
  No change | 33 (78%) | 39 (91%) |  |  |
  Worsening in 1 subregion | 4 (10%) | 3 (7%) |  |  |
  Worsening in 2 subregions | 0 | 0 |  |  |
  Worsening in 3 subregions | 0 | 1 (2%) |  |  |
 Maximum change in score across all subregions: | ||||
  No changec | 38 (90%) | 37 (86%) |  | 0.75a |
  Within-grade worsening | 0 | 2 (5%) |  |  |
  Worsening by 1 grade | 4 (10%) | 4 (9%) |  |  |
  Any subregion with improvement (including within-grade changes) | 7 (17%) | 3 (7%) | 10 (−6–26) |  |
  Any subregion with worsening (including within-grade changes) | 4 (10%) | 6 (14%) | −4 (−20–12) |  |
Osteophyte | ||||
 Increase in no. locations affected by any osteophyte: | 0 | 0 |  |  |
 Change in no. of locations affected by any osteophyte: | ||||
  Improvement 1 subregion | 6 (14%) | 0 |  | 0.01b |
  No Change | 36 (86%) | 42 (100%) |  |  |
  Maximum change in osteophyte score ≥ 1 across all subregions: | 0 | 0 |  |  |
Labrum | ||||
 Maximum change in score across all subregions: | ||||
  No changec | 17 (40%) | 34 (81%) |  | 0.0009a |
  Within-grade worsening | 12 (29%) | 3 (7%) |  |  |
  Worsening by 1 grade | 11 (26%) | 5 (12%) |  |  |
  Worsening by 2 grades | 2 (5%) | 0 |  |  |
  Any subregion with improvement (including within-grade changes) | 7 (17%) | 2 (5%) | 12 (−3–27) |  |
  Any subregion with worsening (including within-grade changes) | 25 (60%) | 8 (19%) | 40 (19–62) |  |
Synovitis | ||||
 Maximum change in score across all subregions: | ||||
  No changec | 14 (33%) | 23 (58%) |  | 0.08a |
  Within-grade worsening | 7 (17%) | 5 (12%) |  |  |
  Worsening by 1 grade | 19 (45%) | 11 (28%) |  |  |
  Worsening by 2 grades | 2 (5%) | 1 (2%) |  |  |
  Any subregion with improvement (including within-grade changes) | 10 (24%) | 10 (24%) | −0 (−21–20) |  |
  Any subregion with worsening (including within-grade changes) | 28 (67%) | 17 (41%) | 25 (2–48) |  |