Fig. 6
From: P2Y2 promotes fibroblasts activation and skeletal muscle fibrosis through AKT, ERK, and PKC
P2Y2 promotes skeletal muscle fibroblast proliferation and migration through AKT, ERK, and PKC. a Mouse skeletal muscle fibroblasts were treated with MK-2206 2HCl, FR 180204, and Calphostin C for 72 h and assessed by CCK-8 assay. b Mouse skeletal muscle fibroblasts were treated with MK-2206 2HCl, FR 180204, and Calphostin C and subjected to Transwell migration assay. c Quantitative analysis of migration rate * p < 0.05 compared to WT. WT, C57Bl/6 N wild type; KO, P2Y2 knockout; MK, MK-2206 2HCl; FR, FR 180204; CC, Calphostin C. * p < 0.05 compared to WT