Fig. 5
From: P2Y2 promotes fibroblasts activation and skeletal muscle fibrosis through AKT, ERK, and PKC
AKT, ERK and PKC mediated the fibrotic activity of P2Y2. a Western blot detected the activation of AKT, ERK, and PKC in wild type and P2Y2 KO mouse skeletal muscle fibroblasts. b The protein levels of α-SMA, collagen I, and CTGF in mouse skeletal muscle fibroblasts treated with TGF-β1 in the presence or absence of MK-2206 2HCl, FR 180204, and Calphostin C were detected by western blot. WT, C57Bl/6 N wild type; KO, P2Y2 knockout