DNA methylation in the OPG/RANK/RANKL pathway is associated with steroid-induced osteonecrosis of the femoral head

Table 6 Area under the curve of the methylation sites

Gene_ID	Area	Sem^a	Youden’s index	95% CI		p value ^b
Gene_ID	Area	Sem^a	Youden’s index	lower limit	upper limit	p value ^b
OPG2_CpG_1	0.679	0.055	0.355	0.57	0.79	0.002
OPG2_CpG_5	0.628	0.059	0.319	0.51	0.74	0.032
OPG2_CpG_10.11	0.622	0.057	0.235	0.51	0.73	0.037
RANK1_CpG_6	0.624	0.057	0.253	0.51	0.74	0.036
RANK1_CpG_15	0.669	0.055	0.330	0.56	0.78	0.004
RANK1_CpG_20	0.662	0.055	0.334	0.56	0.77	0.005
RANK1_CpG_21	0.619	0.059	0.324	0.50	0.74	0.045
RANK2_CpG_10.11	0.750	0.051	0.450	0.65	0.85	< 0.001
RANK2_CpG_15	0.697	0.053	0.394	0.59	0.80	0.001
RANK2_CpG_16	0.760	0.050	0.442	0.66	0.86	< 0.001
RANK2_CpG_21.22	0.617	0.057	0.226	0.51	0.73	0.047
RANK2_CpG_23.24.25.26.27	0.718	0.051	0.352	0.62	0.82	< 0.001
RANK2_CpG_29	0.655	0.056	0.295	0.55	0.76	0.008
RANK2_CpG_30.31	0.688	0.055	0.301	0.58	0.80	0.002
RANK2_CpG_36	0.636	0.057	0.256	0.53	0.75	0.021
RANK3_CpG_1	0.635	0.058	0.315	0.52	0.75	0.023
RANK3_CpG_8	0.778	0.047	0.411	0.69	0.87	< 0.001
RANK3_CpG_10	0.699	0.053	0.318	0.59	0.80	0.001
RANKL1_CpG_1	0.764	0.054	0.479	0.66	0.87	< 0.001
RANKL1_CpG_11	0.645	0.057	0.256	0.53	0.76	0.015
RANKL1_CpG_12.13	0.672	0.059	0.327	0.58	0.79	0.004
RANKL1_CpG_19	0.697	0.056	0.420	0.59	0.81	0.001
RANKL1_CpG_21	0.622	0.059	0.271	0.51	0.74	0.042
RANKL1_CpG_24	0.640	0.058	0.302	0.53	0.75	0.019
RANKL1_CpG_25.26.27	0.710	0.056	0.411	0.60	0.82	< 0.001
RANKL1_CpG_44.45	0.734	0.052	0.396	0.63	0.84	< 0.001
RANKL2_CpG_2	0.629	0.057	0.278	0.52	0.74	0.027
RANKL2_CpG_9.10.11.12	0.738	0.052	0.438	0.64	0.84	< 0.001

ISSN: 1471-2474