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Table 5 Relationship between methylation and steroid-associated osteonecrosis of femoral head

From: DNA methylation in the OPG/RANK/RANKL pathway is associated with steroid-induced osteonecrosis of the femoral head

Gene_ID

OR

95% CI

p value

lower limit

upper limit

OPG2_CpG_1

4.62

1.95

10.95

0.001

OPG2_CpG_5

3.45

1.32

9.02

0.005

RANK1_CpG_6

4.83

1.64

14.25

0.004

RANK1_CpG_15

4.67

1.82

12.01

0.001

RANK1_CpG_20

4.25

1.80

10.05

0.001

RANK2_CpG_10.11

4.76

1.95

11.65

0.001

RANK2_CpG_15

4.17

1.69

10.29

0.002

RANK2_CpG_16

3.71

1.30

10.59

0.014

RANK2_CpG_21.22

2.90

1.19

7.05

0.019

RANK2_CpG_23.24.25.26.27

3.43

1.45

8.10

0.005

RANK2_CpG_29

3.48

1.36

8.91

0.009

RANK2_CpG_36

2.95

1.27

6.86

0.012

RANK3_CpG_8

6.56

2.54

16.93

< 0.001

RANK3_CpG_10

3.91

1.65

9.27

0.002

RANKL1_CpG_1

12.66

4.10

39.11

< 0.001

RANKL1_CpG_12.13

3.57

1.42

8.98

0.007

RANKL1_CpG_14.15

3.10

1.30

7.38

0.011

RANKL1_CpG_19

6.92

2.66

18.00

< 0.001

RANKL1_CpG_21

3.05

1.30

7.12

0.010

RANKL1_CpG_24

2.44

1.05

5.64

0.038

RANKL1_CpG_25.26.27

5.89

2.32

14.93

< 0.001

RANKL1_CpG_44.45

3.84

1.53

9.62

0.004

RANKL1_CpG_46

3.74

1.40

9.97

0.008

RANKL2_CpG_9.10.11.12

3.18

1.31

7.73

0.011

  1. OR odds ratio; CI confidence interval
  2. p < 0.05 indicates statistical significance
  3. p values were calculated by logistic regression adjusted for age and sex