BMC Musculoskeletal Disorders

Table 4 The comparison between groups according to Osteoarthritis Kellgren and Lawrence grade

From: Safety and efficacy of single CHAP Hyaluronan injection versus three injections of linear Hyaluronan in pain relief for knee osteoarthritis: a prospective, 52-week follow-up, randomized, evaluator-blinded study

	OA KL = 2							OA KL = 3
Variables	CHAP-HA (N = 52)			Linear-HA (N = 54)			P^b	CHAP-HA (N = 19)			Linear-HA (N = 15)			P^b
Variables	Mean	SD	P^a	Mean	SD	P^a	P^b	Mean	SD	P^a	Mean	SD	P^a	P^b
VAS pain
Baseline	51.50	19.30	–	50.19	13.53		0.685	56.74	14.59		64.00	9.86		0.109
4th week	27.02	17.94	< 0.001^‡	24.65	19.02	< 0.001^‡	0.579	21.84	19.74	< 0.001^‡	47.67	15.45	0.031^‡	0.001^‡
12th week	21.58	17.12	< 0.001^‡	23.57	20.53	< 0.001^‡	0.591	24.74	21.24	< 0.001^‡	50.33	22.08	0.497	0.007^‡
26th week	19.96	20.93	< 0.001^‡	32.70	23.02	< 0.001^‡	0.003^‡	25.63	23.09	< 0.001^‡	52.67	24.04	0.934	0.009^‡
39th week	30.38	18.88	< 0.001^‡	46.85	21.40	1.000	< 0.001^‡	41.32	22.72	0.059	56.67	22.89	1.000	0.241
52th week	41.25	18.36	0.012^‡	48.89	21.99	1.000	0.034^‡	48.16	18.20	0.225	60.33	22.24	1.000	0.389

OA KL: Osteoarthritis Kellgren and Lawrence grade
VAS: Visual Analogue Scale
a, corrected P value between post-injections and baseline;
b, P value between groups;
‡, significant, P < 0.05

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