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Table 3 Diagnostic performance of ALB, GLB, AGR, PLR, NLR, D-dimer, fibrinogen, FDP, platelet count, PVR, ESR and CRP for PJI

From: Globulin, the albumin-to-globulin ratio, and fibrinogen perform well in the diagnosis of Periprosthetic joint infection

 

AUC (95% CI)

Youden Index (95% CI)

Optimal Cutoff (95% CI)

Sensitivity(%) (95% CI)

Specificity(%) (95% CI)

PPV(%) (95% CI)

NPV(%) (95% CI)

ALB

0.774

(0.713–0.828)

0.450 (0.315–0.541)

37.7 (35.9–39.5)

67.50 (56.00–77.30)

77.54 (69.49–84.01)

63.53 (52.32–73.50)

80.45 (72.49–86.61)

GLB

0.820 (0.763–0.869)

0.474

(0.361–0.542)

31.8 (29.4–34.1)

57.50 (45.95–68.32)

89.86

(83.26–94.14)

76.67 (63.66–86.22)

78.48 (71.10–84.44)

AGR

0.845 (0.790–0.891)

0.597 (0.468–0.690)

1.2 (1.16–1.46)

66.25 (54.72–76.21)

93.48 (87.62–96.78)

85.48 (73.72–92.75)

82.69 (75.64–88.09)

PLR

0.700

(0.635–0.760)

0.376 (0.242–0.465)

177.8 (146.8–214.1)

51.22 (40.01–62.32)

80.58 (72.82–86.60)

60.87 (48.35–72.17)

73.68 (65.81–80.33)

NLR

0.678 (0.612–0.739)

0.337 (0.211–0.444)

2.36 (1.77–2.43)

52.44 (41.18–63.47)

81.30 (73.61–87.21)

62.32 (49.80–73.46)

74.34 (66.51–80.92)

D-dimer

0.683 (0.612–0.749)

0.311 (0.160–0.427)

577 (433–953)

55.22 (42.64–67.21)

75.83 (67.00–82.97)

56.06 (43.35–68.07)

75.21 (66.38–82.40)

Fibrinogen

0.832 (0.775–0.880)

0.574 (0.446–0.665)

3.82 (3.75–4.27)

78.48

(67.52–86.62)

78.95 (70.85–85.34)

68.89 (58.14–78.00)

86.07 (78.35–91.44)

FDP

0.664 (0.592–0.732)

0.271 (0.132–0.362)

4.8

(2.3–6.5)

38.81 (27.38–51.52)

88.33 (80.88–93.24)

65.00 (48.26–78.90)

72.11 (64.01–79.03)

Platelet Count

0.678 (0.612–0.739)

0.323 (0.198–0.414)

294 (215.6–333.0)

52.44 (41.18–63.48)

79.86 (72.04–85.99)

60.56 (48.24–71.74)

74.00 (66.09–80.65)

PVR

0.707 (0.642–0.766)

0.351 (0.230–0.453)

31.89 (27.37–40.71)

48.78 (37.68–59.99)

86.33 (79.23–91.36)

67.80 (54.24–79.03)

74.07 (66.50–80.49)

ESR

0.877

(0.825–0.917)

0.866

(0.547–0.752)

38

(34–44)

81.48

(70.98–88.93)

85.07

(77.65–90.43)

76.74

(66.16–84.89)

88.37

(81.25–93.13)

CRP

0.909

(0.862–0.944)

0.728

(0.622–0.810)

9.63

(9.35–14)

83.95

(73.75–90.85)

88.89

(82.04–93.44)

81.93

(71.63–89.21)

90.23

(83.55–94.48)

  1. AUC area under the curve; CI confidence interval; PPV positive predictive value; NPV negative predictive value; PJI periprosthetic joint infection; ALB albumin; GLB globulin; AGR albumin-to-globulin ratio; PLR platelet-to-lymphocyte ratio; NLR neutrophil-to-lymphocyte ratio; FDP fibrin degradation product; PVR platelet count to mean platelet volume ratio; ESR erythrocyte sedimentation rate; CRP C-reactive protein