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Table 2 Comparison of different biomarkers between PJI and aseptic groups

From: Globulin, the albumin-to-globulin ratio, and fibrinogen perform well in the diagnosis of Periprosthetic joint infection

Variables

Normal Rang

Group A

(n = 31)

Group B

(n = 51)

Group C

(n = 139)

P Value

(A vs. B)

P Value

(A vs. C)

P Value

(B vs. C)

ALBa (g/L)

40–55

35.33 ± 3.67

36.38 ± 4.75

40.29 ± 3.72

0.308

< 0.001

< 0.001

GLBa (g/L)

20–40

33.41 ± 6.62

33.16 ± 5.40

26.78 ± 3.69

0.858

< 0.001

< 0.001

AGRa

1.2–2.4

1.11 ± 0.30

1.13 ± 0.28

1.53 ± 0.24

0.731

< 0.001

< 0.001

PLRb

–

194.12 (124.03–277.24)

163.93 (122.27–218.24)

128.69 (103.49–157.34)

0.308

< 0.001

< 0.001

NLRb

–

2.53 (1.83–3.40)

2.26 (1.62–3.21)

1.75 (1.49–2.28)

0.387

< 0.001

0.001

D-dimerb (ng/ml)

<280

849 (256.5–1078.5)

592.5 (322.5–833.75)

331 (189.5–576)

0.344

0.003

0.001

Fibrinogena (g/L)

2–4

4.54 ± 1.18

4.41 ± 0.81

3.41 ± 0.69

0.572

< 0.001

< 0.001

FDPb (ug/ml)

0–5

6.35 (1.86–10.11)

3.55 (2.48–5.78)

2.75 (1.6–3.8)

0.273

0.007

0.002

Platelet counta

125–350

300.74 ± 92.34

293.55 ± 86.91

243.22 ± 65.33

0.724

0.002

< 0.001

PVRa

–

31.73 ± 11.07

30.54 ± 11.09

23.35 ± 7.73

0.639

< 0.001

< 0.001

ESR (mm/h)b

0–15

55.00 (40.00–66.50)

50.00 (40.00–60.00)

21.50 (13.75–32.50)

0.332

< 0.001

< 0.001

CRP (mg/L)b

0–8

25.75 (12.28–52.28)

20.30 (11.50–31.40)

3.59 (2.23–6.31)

0.371

< 0.001

< 0.001

  1. Group A, acute PJI group; Group B, chronic PJI group; Group C, aseptic failure group
  2. a The values were given as mean ± SD. SD, standard deviation
  3. b The values were given as median with its interquartile range (25th - 75th) in parentheses
  4. PJI periprosthetic joint infection; ALB albumin; GLB globulin; AGR albumin-to-globulin ratio; PLR platelet-to-lymphocyte ratio; NLR neutrophil-to-lymphocyte ratio; FDP fibrin degradation product; PVR platelet count to mean platelet volume ratio; ESR erythrocyte sedimentation rate; CRP C-reactive protein