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Table 3 Comparison of patient characteristics between the PD responders and non-PD responders

From: Association between serum bone biomarker levels and therapeutic response to abatacept in patients with rheumatoid arthritis (RA): a multicenter, prospective, and observational RA ultrasound cohort study in Japan

 

PD responders

n = 30

Non-PD responders

n = 29

p-value

Age, yrs

74 (67–78)

70 (62–74)

0.058

Male, n

8 (26.7)

8 (27.6)

1.00

Disease duration, months

92 (26–258)

39 (10–156)

0.071

Positive RF, n

27 (90.0)

19 (65.5)

0.030

Positive ACPA, n

28 (93.3)

24 (82.8)

0.21

SDAI

25.0 (16.6–36.5)

18.2 (12.2–24.5)

0.0081

Total GS score

19 (13–28)

8 (4–15)

0.0005

Total PD score

11 (7–20)

4 (1–7)

< 0.0001

Dkk-1, pg/ml

3040 (2489–3652)

3699 (2676–4477)

0.026

SOST, pg/ml

2428 (1721–3057)

2803 (2137–3916)

0.058

OC, pg/ml

16,588 (9582–28,327)

17,722 (12512–39,103)

0.54

OPG, pg/ml

958 (749–1190)

945 (839–1534)

0.32

OPN, pg/ml

23,035 (17382–40,435)

22,928 (17305–35,962)

0.93

  1. ACPA Anti-cyclic citrullinated peptide antibody, OC Osteocalcin, OPG Osteoprotegrin, OPN Osteopontin, PD Power Doppler, RF Rheumatoid factor, SDAI Simplified Disease Activity Index, SOST Sclerostin