Table 2 Comparison of serum concentrations of bone biomarkers between healthy controls and RA patients and changes of those over 6 months in the RA patients
| Â | HC | RA | |||||
|---|---|---|---|---|---|---|---|
Baseline | p-value vs. HCa | 3 months | p-value vs. baselineb | 6 months | p-value vs. baselineb | ||
Dkk-1, pg/ml | 4362 (2866–5026) | 3340 (2573–4243) | 0.25 | 3260 (2519–4282) | 0.86 | 3242 (2689–4251) | 0.98 |
SOST, pg/ml | 2509 (1939–3315) | 2616 (1983–3279) | 0.64 | 2588 (2171–3506) | 0.68 | 2738 (2127–3465) | 0.62 |
OC, pg/ml | 28,492(18700–35,923) | 17,109 (11075–35,817) | 0.099 | 18,271 (12754–31,724) | 0.52 | 21,533 (14559–28,715) | 0.26 |
OPG, pg/ml | 1036 (896–1184) | 951 (768–1387) | 0.76 | 1082 (903–1469) | 0.085 | 1181 (903–1469) | 0.016 |
OPN, pg/ml | 9053 (6282–14,337) | 22,928 (17305–37,566) | < 0.0001 | 23,689 (13849–32,156) | 0.76 | 21,818 (13895–33,550) | 0.85 |