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Fig. 5 | BMC Musculoskeletal Disorders

Fig. 5

From: Changes in macrophage and inflammatory cytokine expressions during fracture healing in an ovariectomized mice model

Fig. 5

Impaired inflammatory macrophage formation in the OVX mice during fracture healing. a, b mRNA expressions of M1 (Cd16) and M2 (Cd206) macrophage specific markers in the fracture haematoma/callus of sham and OVX groups. *, p < 0.05; **, p < 0.01 compared with the sham group. n = 6/group. c Dual immunofluorescence staining for M1/M2 macrophages in the fracture haematoma/callus of sham and OVX mice. Blue, DAPI positive nucleus. Red arrow heads, M1 macrophages. Pink arrow heads, M2 macrophages. d Numbers of M1 and M2 macrophages in the fracture haematoma/callus of were quantified. *, p < 0.05 compared with the sham group. n = 6/group. e-g mRNA expressions of MCSF, MCP-1 and IL-4 in the fracture haematoma/callus of sham and OVX groups. **, p < 0.01 compared with the sham group. n = 3/group

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