Table 3 Difference in Mean Change at follow-up by Disease activity (BASDAI), Clinical Improvement (Minimum Clinically Important Improvement (MCII)) and Global Rating of Change Scale
From: Responsiveness of the EuroQoL 5-Dimension (EQ-5D) questionnaire in patients with spondyloarthritis
Disease activity | Change in EQ-5D score | Change in EQ-VAS | ||||
Mean Difference (95% CI) | Effect size | AUC (95% CI) | Mean Difference (95% CI) | Effect size | AUC (95% CI) | |
Unchanged Vs Worsened | 0.07 (0.01,0.13) | 0.66 | 0.74 (0.59,0.88) | 1.08 (-11.14,13.29) | 0.05 | 0.52 (0.36,0.68) |
Improved Vs Unchanged | 0.12 (0.05,0.19) | 1.05 | 0.80 (0.67,0.94) | 8.30 (-4.29,20.89) | 0.40 | 0.63 (0.46,0.79) |
Improved Vs Worsened | 0.19 (0.10,0.28) | 1.35 | 0.93 (0.82,1.00) | 9.38 (-2.71,21.47) | 0.62 | 0.68 (0.46,0.90) |
Improved/unchanged Vs worsened | 0.08 (0.02,0.15) | 0.74 | 0.76 (0.62,0.89) | 2.07 (-9.73,13.87) | 0.10 | 0.54 (0.38,0.69) |
Improved Vs worsen/unchanged | 0.13 (0.06,0.19) | 1.13 | 0.82 (0.69,0.95) | 8.44 (-3.68,20.56) | 0.42 | 0.64 (0.47,0.80) |
Change in EQ-5D score | Change in EQ-VAS | |||||
Clinical improvement | Mean Difference (95% CI) | Effect size | AUC (95% CI) | Mean Difference (95% CI) | Effect size | AUC (95% CI) |
Based on BASDAI MCII | ||||||
Improved Vs Not Improved | 0.16 (0.10,0.22) | 1.36 | 0.85 (0.75,0.95) | 11.33 (0.44,22.23) | 0.56 | 0.65 (0.49,0.82) |
Based on BASFI MCII | ||||||
Improved Vs Not Improved | 0.15 (0.09,0.21) | 1.29 | 0.83 (0.74,0.92) | 10.9 (0.32,21.53) | 0.51 | 0.67 (0.52,0.83) |
Global Rating of Change Scale | Change in EQ-5D score | Change in EQ-VAS | ||||
Mean Difference (95% CI) | Effect size | AUC (95% CI) | Mean Difference (95% CI) | Effect size | AUC (95% CI) | |
Unchanged Vs Worsened | -0.00 (-0.05,0.05) | 0.03 | 0.52 (0.40,0.65) | -2.28 (-11.87,7.32) | 0.11 | 0.48 (0.35,0.60) |
Improved Vs Unchanged | 0.04 (-0.03,0.10) | 0.31 | 0.52 (0.38,0.66) | 15.06 (5.10,25.02) | 0.75 | 0.69 (0.56,0.82) |
Improved Vs Worsened | 0.03 (-0.02,0.09) | 0.30 | 0.55 (0.42,0.69) | 12.79 (3.22,22.35) | 0.66 | 0.66 (0.53,0.78) |
Improved/unchanged Vs worsened | 0.01 (-0.03,0.06) | 0.11 | 0.53 (0.42,0.65) | 3.85 (-4.41,12.11) | 0.19 | 0.55 (0.44,0.67) |
Improved Vs worsen/unchanged | 0.04 (-0.02,0.09) | 0.32 | 0.54 (0.42,0.66) | 13.86 (4.85,22.88) | 0.69 | 0.67 (0.56,0.78) |