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Table 3 Difference in Mean Change at follow-up by Disease activity (BASDAI), Clinical Improvement (Minimum Clinically Important Improvement (MCII)) and Global Rating of Change Scale

From: Responsiveness of the EuroQoL 5-Dimension (EQ-5D) questionnaire in patients with spondyloarthritis

Disease activity Change in EQ-5D score Change in EQ-VAS
Mean Difference (95% CI) Effect size AUC (95% CI) Mean Difference (95% CI) Effect size AUC (95% CI)
Unchanged Vs Worsened 0.07 (0.01,0.13) 0.66 0.74 (0.59,0.88) 1.08 (-11.14,13.29) 0.05 0.52 (0.36,0.68)
Improved Vs Unchanged 0.12 (0.05,0.19) 1.05 0.80 (0.67,0.94) 8.30 (-4.29,20.89) 0.40 0.63 (0.46,0.79)
Improved Vs Worsened 0.19 (0.10,0.28) 1.35 0.93 (0.82,1.00) 9.38 (-2.71,21.47) 0.62 0.68 (0.46,0.90)
Improved/unchanged Vs worsened 0.08 (0.02,0.15) 0.74 0.76 (0.62,0.89) 2.07 (-9.73,13.87) 0.10 0.54 (0.38,0.69)
Improved Vs worsen/unchanged 0.13 (0.06,0.19) 1.13 0.82 (0.69,0.95) 8.44 (-3.68,20.56) 0.42 0.64 (0.47,0.80)
  Change in EQ-5D score Change in EQ-VAS
Clinical improvement Mean Difference (95% CI) Effect size AUC (95% CI) Mean Difference (95% CI) Effect size AUC (95% CI)
Based on BASDAI MCII
 Improved Vs Not Improved 0.16 (0.10,0.22) 1.36 0.85 (0.75,0.95) 11.33 (0.44,22.23) 0.56 0.65 (0.49,0.82)
Based on BASFI MCII
 Improved Vs Not Improved 0.15 (0.09,0.21) 1.29 0.83 (0.74,0.92) 10.9 (0.32,21.53) 0.51 0.67 (0.52,0.83)
Global Rating of Change Scale Change in EQ-5D score Change in EQ-VAS
Mean Difference (95% CI) Effect size AUC (95% CI) Mean Difference (95% CI) Effect size AUC (95% CI)
Unchanged Vs Worsened -0.00 (-0.05,0.05) 0.03 0.52 (0.40,0.65) -2.28 (-11.87,7.32) 0.11 0.48 (0.35,0.60)
Improved Vs Unchanged 0.04 (-0.03,0.10) 0.31 0.52 (0.38,0.66) 15.06 (5.10,25.02) 0.75 0.69 (0.56,0.82)
Improved Vs Worsened 0.03 (-0.02,0.09) 0.30 0.55 (0.42,0.69) 12.79 (3.22,22.35) 0.66 0.66 (0.53,0.78)
Improved/unchanged Vs worsened 0.01 (-0.03,0.06) 0.11 0.53 (0.42,0.65) 3.85 (-4.41,12.11) 0.19 0.55 (0.44,0.67)
Improved Vs worsen/unchanged 0.04 (-0.02,0.09) 0.32 0.54 (0.42,0.66) 13.86 (4.85,22.88) 0.69 0.67 (0.56,0.78)
  1. EQ-5D EuroQol 5-dimension; EQ-VAS EuroQol Visual Analogue Scale; CI confidence interval; AUC Area under the curve; MCII Minimum Clinically Important Improvement