Table 3 Difference in Mean Change at follow-up by Disease activity (BASDAI), Clinical Improvement (Minimum Clinically Important Improvement (MCII)) and Global Rating of Change Scale

Disease activity

Mean Difference (95% CI)

Effect size

AUC (95% CI)

Mean Difference (95% CI)

Effect size

AUC (95% CI)

Unchanged Vs Worsened

0.07 (0.01,0.13)

0.66

0.74 (0.59,0.88)

1.08 (-11.14,13.29)

0.05

0.52 (0.36,0.68)

Improved Vs Unchanged

0.12 (0.05,0.19)

1.05

0.80 (0.67,0.94)

8.30 (-4.29,20.89)

0.40

0.63 (0.46,0.79)

Improved Vs Worsened

0.19 (0.10,0.28)

1.35

0.93 (0.82,1.00)

9.38 (-2.71,21.47)

0.62

0.68 (0.46,0.90)

Improved/unchanged Vs worsened

0.08 (0.02,0.15)

0.74

0.76 (0.62,0.89)

2.07 (-9.73,13.87)

0.10

0.54 (0.38,0.69)

Improved Vs worsen/unchanged

0.13 (0.06,0.19)

1.13

0.82 (0.69,0.95)

8.44 (-3.68,20.56)

0.42

0.64 (0.47,0.80)

Clinical improvement

Mean Difference (95% CI)

Effect size

AUC (95% CI)

Mean Difference (95% CI)

Effect size

AUC (95% CI)

 Improved Vs Not Improved

0.16 (0.10,0.22)

1.36

0.85 (0.75,0.95)

11.33 (0.44,22.23)

0.56

0.65 (0.49,0.82)

 Improved Vs Not Improved

0.15 (0.09,0.21)

1.29

0.83 (0.74,0.92)

10.9 (0.32,21.53)

0.51

0.67 (0.52,0.83)

Global Rating of Change Scale

Mean Difference (95% CI)

Effect size

AUC (95% CI)

Mean Difference (95% CI)

Effect size

AUC (95% CI)

Unchanged Vs Worsened

-0.00 (-0.05,0.05)

0.03

0.52 (0.40,0.65)

-2.28 (-11.87,7.32)

0.11

0.48 (0.35,0.60)

Improved Vs Unchanged

0.04 (-0.03,0.10)

0.31

0.52 (0.38,0.66)

15.06 (5.10,25.02)

0.75

0.69 (0.56,0.82)

Improved Vs Worsened

0.03 (-0.02,0.09)

0.30

0.55 (0.42,0.69)

12.79 (3.22,22.35)

0.66

0.66 (0.53,0.78)

Improved/unchanged Vs worsened

0.01 (-0.03,0.06)

0.11

0.53 (0.42,0.65)

3.85 (-4.41,12.11)

0.19

0.55 (0.44,0.67)

Improved Vs worsen/unchanged

0.04 (-0.02,0.09)

0.32

0.54 (0.42,0.66)

13.86 (4.85,22.88)

0.69

0.67 (0.56,0.78)