The association between TP53 rs1625895 polymorphism and the risk of sarcopenic obesity in Iranian older adults: a case-control study

Table 1 Comparison of the sarcopenic, sarcopenic obesity and healthy participants regarding baseline characteristics

Variables	Total (n = 206)	Sarcopenic (n = 45)	SO (n = 33)	Healthy (n = 131)	P-value^*	P-value^**
Age, years	70.45 ± 4.83	73.27 ± 5.94	70.0 ± 4.47	69.66 ± 4.16	< 0.0001	0.666
WC, cm	93.55 ± 9.05	87.28 ± 8.58	102.31 ± 7.46	93.60 ± 7.7	< 0.0001	< 0.0001
CC, cm	35.04 ± 3.27	31.93 ± 2.45	37.66 ± 3.10	35.46 ± 2.7	< 0.0001	< 0.0001
BMI, kg/m²	27.01 ± 4.45	23.47 ± 3.17	33.48 ± 3.16	26.7 ± 3.3	< 0.0001	< 0.0001
ALM, kg	19.03 ± 4.76	16.32 ± 3.28	15.62 ± 2.54	20.7 ± 4.84	< 0.0001	< 0.0001
FFM, kg	45.31 ± 8.28	40.31 ± 5.95	38.73 ± 4.45	48.4 ± 8.32	< 0.0001	< 0.0001
FM, kg	24.26 ± 8.22	19.39 ± 6.19	36.64 ± 5.39	23.1 ± 6.3	< 0.0001	< 0.0001
FM, %	34.63 ± 9.18	32.07 ± 7.71	48.51 ± 2.68	32.3 ± 7.7	0.842	< 0.0001
SMI, kg/m²	7.24 ± 1.12	6.33 ± 0.72	6.92 ± 0.80	7.6 ± 1.1	< 0.0001	0.002
HGS, kg	43.45 ±	33.87 ± 12.61	30.78 ± 9.24	49.5 ± 18.2	< 0.0001	< 0.0001
GS, m/s	17.98	0.70 ± 0.14	0.75 ± 0.18	0.93 ± 0.75	0.046	0.164
FM/FFM	0.86 ± 0.61	0.49 ± 0.18	0.94 ± 0.10	0.49 ± 0.16	0.989	< 0.0001
*Albumin, g/dl	4 (0.3)	3.9 (0.4)	3.9 (0.4)	4 (0.3)	0.005	0.009
*Creatinine, mg/dl	0.9 (0.2)	0.9 (0.2)	0.8 (18)	0.9 (0.15)	0.624	0.008
*BUN, mg/dl	14 (5)	15 (4)	13 (4)	14 (5)	0.904	0.138
*FBS, mg/dl	103.5	101 (20)	100.5 (18)	105 (20)	0.622	0.067
*Cholesterol, mg/dl	180 (57)	184 (66)	186.5 (71.5)	180 (56)	0.507	0.463
*LDL-C, g/dl	98.5 (52)	102 (63)	94 (55)	97 (49)	0.650	0.982
*HDL-C, mg/dl	50 (14)	49 (6)	59 (14.75)	50 (7)	0.878	0.002
*Triglycerides, mg/dl	125 (80.5)	107 (56)	120 (80)	132 (79)	0.110	0.205

Abbreviations: SO sarcopenic obesity; WC waist circumference; CC calf circumference; BMI body mass index; FFM fat-free mass; FM fat mass; ALM appendicular lean muscle mass; SMI skeletal muscle mass; HGS hand grip strength; GS gait speed
^* Comparison between sarcopenic and healthy participants
^** Comparison between sarcopenic obesity and healthy obesity participants
Independent t-test or Mann-Whitney U test was used. P-value<.0.05 are considered statistically significant

ISSN: 1471-2474