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Table 4 Comparison between the VS and non-VS groups (univariate analysis)

From: Risk factors associated with cervical spine lesions in patients with rheumatoid arthritis: an observational study

  VS group (n = 31) Non-VS group (n = 154) P-value*
Sex (male:female) 4:27 2:146 0.11
Age (years) (IQR) 67 (63−72) 68 (61−75) 0.36
Age of onset (years) (IQR) 48 (38−56) 55 (44−66) < 0.01
RA duration (years) (IQR) 18 (13−25) 9 (4−21) < 0.01
CRP level (mg/dL) (IQR) 0.7 (0.4−1.5) 0.3 (0.1−1.0) < 0.01
RF positive (n) 55 % (17/31) 64 % (98/154) 0.36
MMP3 positive (n) 61 % (19/31) 66 % (102/154) 0.60
DAS28-CRP (IQR) 2.9 (2.2−3.6) 2.2 (1.7−3.0) 0.55
RA stage III or IV (n) 97 % (30/31) 64 % (99/154) < 0.01
Prednisolone (n) 68 % (21/31) 45 % (69/154) 0.02
MTX (n) 52 % (16/31) 65 % (100/154) 0.16
Biological agents (n) 42 % (13/31) 28 % (43/154) 0.12
BMD of the lumbar spine (IQR) 79 % (74−92) 82 (71−93) 0.66
BMD of the femoral neck (IQR) 60 % (49–67) 68 (60–77) 0.04
Previous joint surgery (n) 68 % (21/31) 26 % (40/154) < 0.01
  1. BMD bone mineral density, CRP C-reactive protein, DAS28-CRP Disease Activity Score based on C-reactive protein, MTX methotrexate, RA rheumatoid arthritis, VS vertical subluxation, IQR interquartile range
  2. *The P-value was calculated using the Fisher exact test, Mann−Whitney U test, and Student t-test, or chi-square test