Fig. 8

Sensorimotor changes across weeks. a Cold temperature sensitivity assayed using a temperature place preference instrument in the last week of task performed (week 12) in TASK rats, and at an age-matched time points in control rats. b Reflexive grip strength was assayed at baseline after onset of food restriction, after the 6-week shaping period (task week 0, and every 3 weeks through task week 12). Data are reported bilaterally for the TASK rats (TASK-Ac and TASK-Tx, n = 10/group) and control rats (C-Ac and C-Tx; n = 5 rats/group). c Observed incidence of sitting in the corner (suggestive of task avoidance) during an active task session rather than reaching and pulling for longer than 3 min. Symbols: *: p < 0.0, compared to TASK-Tx group; #: p < 0.05, compared to baseline; †: p < 0.05, compared to age- and treatment-matched control animals. Mean ± 95% CI shown