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Table 4 The number of patients of true positive (TP), false negative (FN), false positive (FP) and true negative (TN) and the sensitivity (SE), specificity (SP), positive predictive value (PPV) and negative predictive value (NPV), and the prevalence of the definition-positives for 32 claims-based definitions for RA

From: The validity of the claims-based definition of rheumatoid arthritis evaluated in 64 hospitals in Japan

No Definition TP (N) FN (N) FP (N) TN (N) SE(95% CI) (%) SP (95% CI) (%) PPV (95% CI) (%) NPV (95% CI) (%) Prevalence of -positives (%)definition
1 1A 63 10 48 12,861 86.3 (78.4–94.2) 99.6 (99.5–99.7) 56.8 (47.5–66.0) 99.9 (99.9–100.0) 0.86%
2 1B 61 12 43 12,866 83.6 (75.1–92.1) 99.7 (99.6–99.8) 58.7 (49.2–68.1) 99.9 (99.9–100.0) 0.80%
3 2A 45 28 17 12,892 61.6 (50.5–72.8) 99.9 (99.8–99.9) 72.6 (61.5–83.7) 99.8 (99.7–99.9) 0.48%
4 2B 44 29 15 12,894 60.3 (49.0–71.5) 99.9 (99.8–99.9) 74.6 (63.5–85.7) 99.8 (99.7–99.9) 0.45%
5 1A and 2A 43 30 7 12,902 58.9 (47.6–70.2) 99.9 (99.9–100.0) 86.0 (76.4–95.6) 99.8 (99.7–99.9) 0.39%
6 1A and 2B 42 31 5 12,904 57.5 (46.2–68.9) 100.0 (99.9–100.0) 89.4 (80.5–98.2) 99.8 (99.7–99.8) 0.36%
7 1B and 2A 43 30 5 12,904 58.9 (47.6–70.2) 100.0 (99.9–100.0) 89.6 (80.9–98.2) 99.8 (99.7–99.9) 0.37%
8 1B and 2B 42 31 5 12,904 57.5 (46.2–68.9) 100.0 (99.9–100.0) 89.4 (80.5–98.2) 99.8 (99.7–99.8) 0.36%
9 1A and 3A 26 47 21 12,888 35.6 (24.6–46.6) 99.8 (99.8–99.9) 55.3 (41.1–69.5) 99.6 (99.5–99.7) 0.36%
10 1B and 3A 26 47 19 12,890 35.6 (24.6–46.6) 99.9 (99.8–99.9) 57.8 (43.3–72.2) 99.6 (99.5–99.7) 0.35%
11 1A and 3B 19 54 15 12,894 26.0 (16.0–36.1) 99.9 (99.8–99.9) 55.9 (39.2–72.6) 99.6 (99.5–99.7) 0.26%
12 1B and 3B 19 54 14 12,895 26.0 (16.0–36.1) 99.9 (99.8–99.9) 57.6 (40.7–74.4) 99.6 (99.5–99.7) 0.25%
13 1A and (2A or 3A) 53 20 23 12,886 72.6 (62.4–82.8) 99.8 (99.7–99.9) 69.7 (59.4–80.1) 99.8 (99.8–99.9) 0.59%
14 1A and (2B or 3A) 53 20 21 12,888 72.6 (62.4–82.8) 99.8 (99.8–99.9) 71.6 (61.3–81.9) 99.8 (99.8–99.9) 0.57%
15 1B and (2A or 3A) 53 20 19 12,890 72.6 (62.4–82.8) 99.9 (99.8–99.9) 73.6 (63.4–83.8) 99.8 (99.8–99.9) 0.55%
16 1B and (2B or 3A) 53 20 19 12,890 72.6 (62.4–82.8) 99.9 (99.8–99.9) 73.6 (63.4–83.8) 99.8 (99.8–99.9) 0.55%
17 1A and (2A or 3B) 49 24 17 12,892 67.1 (56.3–77.9) 99.9 (99.8–99.9) 74.2 (63.7–84.8) 99.8 (99.7–99.9) 0.51%
18 1A and (2B or 3B) 48 25 15 12,894 65.8 (54.9–76.6) 99.9 (99.8–99.9) 76.2 (65.7–86.7) 99.8 (99.7–99.9) 0.49%
19 1B and (2A or 3B) 49 24 14 12,895 67.1 (56.3–77.9) 99.9 (99.8–99.9) 77.8 (67.5–88.0) 99.8 (99.7–99.9) 0.49%
20 1B and (2B or 3B) 48 25 14 12,895 65.8 (54.9–76.6) 99.9 (99.8–99.9) 77.4 (67.0–87.8) 99.8 (99.7–99.9) 0.48%
21 1A and (2A or (3A and 4)) 53 20 16 12,893 72.6 (62.4–82.8) 99.9 (99.8–99.9) 76.8 (66.9–86.8) 99.8 (99.8–99.9) 0.53%
22 1A and (2B or (3A and 4)) 53 20 14 12,895 72.6 (62.4–82.8) 99.9 (99.8–99.9) 79.1 (69.4–88.8) 99.8 (99.8–99.9) 0.52%
23 1B and (2A or (3A and 4)) 53 20 13 12,896 72.6 (62.4–82.8) 99.9 (99.8–100.0) 80.3 (70.7–89.9) 99.8 (99.8–99.9) 0.51%
24 1B and (2B or (3A and 4)) 53 20 13 12,896 72.6 (62.4–82.8) 99.9 (99.8–100.0) 80.3 (70.7–89.9) 99.8 (99.8–99.9) 0.51%
25 1A and (2A or (3B and 4)) 49 24 11 12,898 67.1 (56.3–77.9) 99.9 (99.9–100.0) 81.7 (71.9–91.5) 99.8 (99.7–99.9) 0.46%
26 1A and (2B or (3B and 4)) 48 25 9 12,900 65.8 (54.9–76.6) 99.9 (99.9–100.0) 84.2 (74.7–93.7) 99.8 (99.7–99.9) 0.44%
27 1B and (2A or (3B and 4)) 49 24 9 12,900 67.1 (56.3–77.9) 99.9 (99.9–100.0) 84.5 (75.2–93.8) 99.8 (99.7–99.9) 0.45%
28 1B and (2B or (3B and 4)) 48 25 9 12,900 65.8 (54.9–76.6) 99.9 (99.9–100.0) 84.2 (74.7–93.7) 99.8 (99.7–99.9) 0.44%
29 2A or (1A and 3A and 4) 55 18 26 12,883 75.3 (65.5–85.2) 99.8 (99.7–99.9) 67.9 (57.7–78.1) 99.9 (99.8–99.9) 0.62%
30 2B or (1A and 3A and 4) 55 18 24 12,885 75.3 (65.5–85.2) 99.8 (99.7–99.9) 69.6 (59.5–79.8) 99.9 (99.8–99.9) 0.61%
31 2A or (1B and 3A and 4) 55 18 25 12,884 75.3 (65.5–85.2) 99.8 (99.7–99.9) 68.8 (58.6–78.9) 99.9 (99.8–99.9) 0.62%
32 2B or (1B and 3A and 4) 55 18 23 12,886 75.3 (65.5–85.2) 99.8 (99.7–99.9) 70.5 (60.4–80.6) 99.9 (99.8–99.9) 0.60%
  1. The inclusion criteria (1A, 1B, 2A, 2B, 3A, 3B) and exclusion criteria (4) used in the definition are given in Table 2