Table 4 The number of patients of true positive (TP), false negative (FN), false positive (FP) and true negative (TN) and the sensitivity (SE), specificity (SP), positive predictive value (PPV) and negative predictive value (NPV), and the prevalence of the definition-positives for 32 claims-based definitions for RA

1

1A

63

10

48

12,861

86.3 (78.4–94.2)

99.6 (99.5–99.7)

56.8 (47.5–66.0)

99.9 (99.9–100.0)

0.86%

2

1B

61

12

43

12,866

83.6 (75.1–92.1)

99.7 (99.6–99.8)

58.7 (49.2–68.1)

99.9 (99.9–100.0)

0.80%

3

2A

45

28

17

12,892

61.6 (50.5–72.8)

99.9 (99.8–99.9)

72.6 (61.5–83.7)

99.8 (99.7–99.9)

0.48%

4

2B

44

29

15

12,894

60.3 (49.0–71.5)

99.9 (99.8–99.9)

74.6 (63.5–85.7)

99.8 (99.7–99.9)

0.45%

5

1A and 2A

43

30

7

12,902

58.9 (47.6–70.2)

99.9 (99.9–100.0)

86.0 (76.4–95.6)

99.8 (99.7–99.9)

0.39%

6

1A and 2B

42

31

5

12,904

57.5 (46.2–68.9)

100.0 (99.9–100.0)

89.4 (80.5–98.2)

99.8 (99.7–99.8)

0.36%

7

1B and 2A

43

30

5

12,904

58.9 (47.6–70.2)

100.0 (99.9–100.0)

89.6 (80.9–98.2)

99.8 (99.7–99.9)

0.37%

8

1B and 2B

42

31

5

12,904

57.5 (46.2–68.9)

100.0 (99.9–100.0)

89.4 (80.5–98.2)

99.8 (99.7–99.8)

0.36%

9

1A and 3A

26

47

21

12,888

35.6 (24.6–46.6)

99.8 (99.8–99.9)

55.3 (41.1–69.5)

99.6 (99.5–99.7)

0.36%

10

1B and 3A

26

47

19

12,890

35.6 (24.6–46.6)

99.9 (99.8–99.9)

57.8 (43.3–72.2)

99.6 (99.5–99.7)

0.35%

11

1A and 3B

19

54

15

12,894

26.0 (16.0–36.1)

99.9 (99.8–99.9)

55.9 (39.2–72.6)

99.6 (99.5–99.7)

0.26%

12

1B and 3B

19

54

14

12,895

26.0 (16.0–36.1)

99.9 (99.8–99.9)

57.6 (40.7–74.4)

99.6 (99.5–99.7)

0.25%

13

1A and (2A or 3A)

53

20

23

12,886

72.6 (62.4–82.8)

99.8 (99.7–99.9)

69.7 (59.4–80.1)

99.8 (99.8–99.9)

0.59%

14

1A and (2B or 3A)

53

20

21

12,888

72.6 (62.4–82.8)

99.8 (99.8–99.9)

71.6 (61.3–81.9)

99.8 (99.8–99.9)

0.57%

15

1B and (2A or 3A)

53

20

19

12,890

72.6 (62.4–82.8)

99.9 (99.8–99.9)

73.6 (63.4–83.8)

99.8 (99.8–99.9)

0.55%

16

1B and (2B or 3A)

53

20

19

12,890

72.6 (62.4–82.8)

99.9 (99.8–99.9)

73.6 (63.4–83.8)

99.8 (99.8–99.9)

0.55%

17

1A and (2A or 3B)

49

24

17

12,892

67.1 (56.3–77.9)

99.9 (99.8–99.9)

74.2 (63.7–84.8)

99.8 (99.7–99.9)

0.51%

18

1A and (2B or 3B)

48

25

15

12,894

65.8 (54.9–76.6)

99.9 (99.8–99.9)

76.2 (65.7–86.7)

99.8 (99.7–99.9)

0.49%

19

1B and (2A or 3B)

49

24

14

12,895

67.1 (56.3–77.9)

99.9 (99.8–99.9)

77.8 (67.5–88.0)

99.8 (99.7–99.9)

0.49%

20

1B and (2B or 3B)

48

25

14

12,895

65.8 (54.9–76.6)

99.9 (99.8–99.9)

77.4 (67.0–87.8)

99.8 (99.7–99.9)

0.48%

21

1A and (2A or (3A and 4))

53

20

16

12,893

72.6 (62.4–82.8)

99.9 (99.8–99.9)

76.8 (66.9–86.8)

99.8 (99.8–99.9)

0.53%

22

1A and (2B or (3A and 4))

53

20

14

12,895

72.6 (62.4–82.8)

99.9 (99.8–99.9)

79.1 (69.4–88.8)

99.8 (99.8–99.9)

0.52%

23

1B and (2A or (3A and 4))

53

20

13

12,896

72.6 (62.4–82.8)

99.9 (99.8–100.0)

80.3 (70.7–89.9)

99.8 (99.8–99.9)

0.51%

24

1B and (2B or (3A and 4))

53

20

13

12,896

72.6 (62.4–82.8)

99.9 (99.8–100.0)

80.3 (70.7–89.9)

99.8 (99.8–99.9)

0.51%

25

1A and (2A or (3B and 4))

49

24

11

12,898

67.1 (56.3–77.9)

99.9 (99.9–100.0)

81.7 (71.9–91.5)

99.8 (99.7–99.9)

0.46%

26

1A and (2B or (3B and 4))

48

25

9

12,900

65.8 (54.9–76.6)

99.9 (99.9–100.0)

84.2 (74.7–93.7)

99.8 (99.7–99.9)

0.44%

27

1B and (2A or (3B and 4))

49

24

9

12,900

67.1 (56.3–77.9)

99.9 (99.9–100.0)

84.5 (75.2–93.8)

99.8 (99.7–99.9)

0.45%

28

1B and (2B or (3B and 4))

48

25

9

12,900

65.8 (54.9–76.6)

99.9 (99.9–100.0)

84.2 (74.7–93.7)

99.8 (99.7–99.9)

0.44%

29

2A or (1A and 3A and 4)

55

18

26

12,883

75.3 (65.5–85.2)

99.8 (99.7–99.9)

67.9 (57.7–78.1)

99.9 (99.8–99.9)

0.62%

30

2B or (1A and 3A and 4)

55

18

24

12,885

75.3 (65.5–85.2)

99.8 (99.7–99.9)

69.6 (59.5–79.8)

99.9 (99.8–99.9)

0.61%

31

2A or (1B and 3A and 4)

55

18

25

12,884

75.3 (65.5–85.2)

99.8 (99.7–99.9)

68.8 (58.6–78.9)

99.9 (99.8–99.9)

0.62%

32

2B or (1B and 3A and 4)

55

18

23

12,886

75.3 (65.5–85.2)

99.8 (99.7–99.9)

70.5 (60.4–80.6)

99.9 (99.8–99.9)

0.60%