Efficacy and safety of a single intra-articular injection of 6 ml Hylan G-F 20 compared to placebo in Chinese patients with symptomatic knee osteoarthritis

Table 5 Mean change in COGA from baseline over 26 weeks

	Placebo (N = 220)	Single 6 ml Hylan G-F 20 injection (N = 218)
Baseline
Number	220	216
Mean (SD)	5.5 (1.3)	5.7 (1.2)
Median	5.0	6.0
Min; Max	2; 9	2; 9
Change from baseline over 26 weeks
LS Mean (SE)	−2.145 (0.095)	−2.225 (0.094)
LS Mean Difference (SE) vs. Placebo		−0.080 (0.120)
95% CI		(−0.316 to 0.155)
P-value		0.5036

Least-square (LS) means, standard errors (SE) and p-value are taken from repeated measures of Covariance analysis. The model includes treatment groups (Single 6 ml Hylan G-F 20 injection and placebo), site, visit and visit by treatment interaction, as well as the baseline COGA score as a covariate. Included are patients who have measurements at baseline and at least one post-baseline value

ISSN: 1471-2474