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Table 5 Mean change in COGA from baseline over 26 weeks

From: Efficacy and safety of a single intra-articular injection of 6 ml Hylan G-F 20 compared to placebo in Chinese patients with symptomatic knee osteoarthritis

  Placebo (N = 220) Single 6 ml Hylan G-F 20 injection (N = 218)
Baseline
 Number 220 216
 Mean (SD) 5.5 (1.3) 5.7 (1.2)
 Median 5.0 6.0
 Min; Max 2; 9 2; 9
Change from baseline over 26 weeks
 LS Mean (SE) −2.145 (0.095) −2.225 (0.094)
 LS Mean Difference (SE) vs. Placebo   −0.080 (0.120)
 95% CI   (−0.316 to 0.155)
P-value   0.5036
  1. Least-square (LS) means, standard errors (SE) and p-value are taken from repeated measures of Covariance analysis. The model includes treatment groups (Single 6 ml Hylan G-F 20 injection and placebo), site, visit and visit by treatment interaction, as well as the baseline COGA score as a covariate. Included are patients who have measurements at baseline and at least one post-baseline value