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Table 4 Mean change in PTGA from baseline over 26 weeks

From: Efficacy and safety of a single intra-articular injection of 6 ml Hylan G-F 20 compared to placebo in Chinese patients with symptomatic knee osteoarthritis

  Placebo (N = 220) Single 6 ml Hylan G-F 20 injection (N = 218)
Baseline
 Number 220 216
 Mean (SD) 5.7 (1.4) 5.8 (1.4)
 Median 6.0 6.0
 Min; Max 2; 10 2; 9
Change from baseline over 26 weeks
 LS Mean (SE) −2.138 (0.104) −2.144 (0.102)
 LS Mean Difference (SE) vs. Placebo   −0.006 (0.130)
 95% CI   (−0.262 to 0.250)
 P-value   0.9621
  1. Least-square (LS) means, standard errors (SE) and p-value are taken from repeated measures of Covariance analysis. The model includes treatment groups (Single 6 ml Hylan G-F 20 injection and placebo), site, visit and visit by treatment interaction, as well as the baseline PTGA score as a covariate. Included are patients who have measurements at baseline and at least one post-baseline value