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Table 4 Mean change in PTGA from baseline over 26 weeks

From: Efficacy and safety of a single intra-articular injection of 6 ml Hylan G-F 20 compared to placebo in Chinese patients with symptomatic knee osteoarthritis

 

Placebo (N = 220)

Single 6 ml Hylan G-F 20 injection (N = 218)

Baseline

 Number

220

216

 Mean (SD)

5.7 (1.4)

5.8 (1.4)

 Median

6.0

6.0

 Min; Max

2; 10

2; 9

Change from baseline over 26 weeks

 LS Mean (SE)

−2.138 (0.104)

−2.144 (0.102)

 LS Mean Difference (SE) vs. Placebo

 

−0.006 (0.130)

 95% CI

 

(−0.262 to 0.250)

 P-value

 

0.9621

  1. Least-square (LS) means, standard errors (SE) and p-value are taken from repeated measures of Covariance analysis. The model includes treatment groups (Single 6 ml Hylan G-F 20 injection and placebo), site, visit and visit by treatment interaction, as well as the baseline PTGA score as a covariate. Included are patients who have measurements at baseline and at least one post-baseline value