Efficacy and safety of a single intra-articular injection of 6 ml Hylan G-F 20 compared to placebo in Chinese patients with symptomatic knee osteoarthritis

Table 2 Mean change in WOMAC A1 from baseline over 26 weeks

	Placebo (N = 220)	Single 6 ml Hylan G-F 20 injection (N = 218)
Baseline
Number	220	216
Mean (SD)	5.2 (1.3)	5.3 (1.2)
Median	5.0	5.0
Min; Max	0; 8	1; 8
Change from baseline over 26 weeks
LS Mean (SE)	−2.271 (0.110)	−2.146 (0.108)
LS Mean Difference (SE) vs. Placebo		0.125 (0.137)
95% CI		(−0.144 to 0.395)
P-value		0.3610

Least-square (LS) means, standard errors (SE) and p-value are taken from repeated measures of Covariance analysis. The model includes treatment groups (Single 6 ml Hylan G-F 20 injection and placebo), site, visit and visit by treatment interaction, as well as the baseline WOMAC A1 score as a covariate. Included are patients who have measurements at baseline and at least one post-baseline value

ISSN: 1471-2474