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Table 2 Association results for RA antibody interactions with anti-TNF response

From: Interactions between rheumatoid arthritis antibodies are associated with the response to anti-tumor necrosis factor therapy

 

Regression coefficient (95%CI),

P-value

Antibody pair

Interaction effect

Antibody #1 main effect

Antibody #2 main effect

#1: Anti-CCP

#2: RF

2.74 (1.20,4.26), P = 0.00068

−1.21 (−2.14, −0.28), P = 0.012

−2.24 (−3.57, − 0.91), P = 0.0013

#1: RF

#2: Anti-PAD4

− 2.7e-4 (−7.5e-4,1.9e-4), P = 0.25

0.17 (− 0.89,1.21), P = 0.75

1.9e-4 (− 2.1e-4,5.9e-4), P = 0.34

#1: Anti-PAD4

#2: Anti-CarP

−1.3e-6 (− 2.20–6,3.8e-6), P = 0.0062

2.2e-4 (− 3.6e-5,4.8e-4), P = 0.090

1.3e-3 (9.6e-5,2.5e-3), P = 0.035

#1: Anti-CCP

#2: Anti-PAD4

−2.5e-4 (− 7.5e-4,2.5e-4), P = 0.33

0.12 (− 0.94,1.18), P = 0.83

1.8e-4 (− 2.6e-4,6.2e-4), P = 0.41

#1: Anti-CCP

#2: Anti-CarP

8.9e-4 (−8.9e-4,2.7e-3), P = 0.32

−0.45 (− 1.38,0.48), P = 0.34

−8.4e-4 (− 2.5e-3,7.9e-4), P = 0.31

#1: RF

#2: Anti-CarP

−5.39e-4 (− 3.1e-3,1.9e-3), P = 0.67

− 0.17 (− 0.99,0.65), P = 0.67

3.87e-3 (− 2e-3,2.8e-3), P = 0.75

  1. Each row shows the association results for each of the six possible pairwise interactions between the four RA antibodies and anti-TNF treatment response, adjusting for baseline DAS28, sex and age. Regression coefficients (β value) with 95% confidence intervals (CI) and P values for association are shown for the interaction term (first column) and for the independent effect of each antibody (second and third columns). In bold, interaction P-values that are significant after correcting for multiple testing. A highly significant interaction was found for anti-CCP:RF and anti-PAD4:anti-CarP interactions with anti-TNF response. None of the remaining four antibody interactions showed a significant association, even at the nominal (P < 0.05) level