Table 4 correlation of cytokine levels versus clinical outcomes 3 and 12 months after knee surgery
Cytokines | KOOS 3 months P-value (coef.) | KOOS 12 months P-value (coef.) | EQ 5D 3 months P-value (coef.) | EQ 5D 12 months P-value (coef.) | VAS 3 months, rest P-value (coef.) | VAS 12 months, rest P-value (coef.) | VAS 3 months, mobilization P-value (coef.) | VAS 12 months, mobilization P-value (coef.) | Mobilization level 3 months P-value (coef.) | Mobilization level 12 months P-value (coef.) | Swelling 3 months P-value (coef.) | Swelling 12 months P-value (coef.) | EQ 5 D VAS 3 months P-value (coef.) | EQ 5 D VAS 12 months P-value (coef.) | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Pro-inflammatory | IL-1α | – | – | – | 0.03 (0.65) | – | – | – | – | – | – | – | – | – | 0.04 (0.60) |
IL-1β | – | – | – | – | – | – | – | 0.0015 (−0.55) | – | – | – | – | – | – | |
IL-2 | – | – | – | – | – | – | – | 0.0019 (0.82) | – | – | – | – | – | – | |
IL-6 | – | – | – | – | – | 0.04 (−0.62) | 0.03 (0.69) | – | – | – | – | – | – | – | |
IL-8 | – | – | – | – | – | – | – | 0.018 (0.72) | – | – | – | – | – | – | |
IL-12p70 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | |
TNF-α | – | – | – | – | – | 0.04 (0.60) | – | 0.02 (0.68) | – | – | – | – | – | – | |
TNF-β | – | – | – | – | – | – | – | – | – | – | 0.04 (−0.61) | – | – | ||
IFN-y | – | – | – | – | – | – | – | – | – | – | – | – | – | – | |
MMP-1 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | |
MMP-3 | – | – | – | – | – | 0.0053 (−0.77) | – | – | – | – | – | – | – | – | |
MMP-9 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | |
Anti-inflammatory | IL-1RA | – | – | – | – | – | – | – | 0.0094 (0.73) | – | – | – | – | – | – |
IL-4 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | |
IL-10 | – | – | – | – | – | – | – | 0.047 (0.60) | – | – | – | – | – | – | |
IL-13 | – | 0.036 (0.63) | – | – | – | – | – | – | – | – | – | – | – | – | |
Cartilage degradation | ACG | – | – | – | – | – | – | – | – | – | – | – | – | – | – |
CTX2 | – | – | – | – | – | – | – | – | – | – | – | – | – | – | |
Metabolic | b-FGF | – | – | – | – | – | 0.0043 (0.78) | – | – | – | – | – | – | – | – |
TGF-β1 | – | 0.0039 (0.78) | – | 0.007 (0.75) | – | – | – | – | – | 0.0051 (0.77) | – | – | – | 0.02 (0.65) | |
TGF-β2 | – | – | – | – | – | – | – | 0.047 (0.60) | – | – | – | – | – | – | |
TGF-β3 | – | – | – | – | – | – | – | – | – | – | 0.0071 (0.85) | – | – | – |