Skip to main content
Fig. 3 | BMC Musculoskeletal Disorders

Fig. 3

From: Anti-IL17 antibody Secukinumab therapy is associated with ossification in giant cell tumor of bone: a case report of pathologic similarities and therapeutic potential similar to Denosumab

Fig. 3

H&E histology. a Core needle biopsy specimen containing rare, multinucleated giant cells scattered within areas of new bone formation and osteoid matrix lined by osteoblastic riming. The very limited number of giant cells is not typical for a diagnosis of therapy-naïve GCTB. b Hemosiderin laden deposition; bloody spaces surrounded by cellular cyst wall. Findings are in keeping with a secondary aneurysmal bone cyst. c Material from the intralesional curetting shows confluent areas of osteoid matrix deposition, closely resembling the features seen in denosumab treated GCTB. d New woven bone formation lined by reactive osteoblastic cells, devoided by multinucleated osteoclasts. e Only one cellular focus showing a cluster of multinucleated giant cells were noted, admixed with mononuclear cells and hemosiderin deposition. f Immunohistochemical staining with H3.3G34W showed strong nuclear positivity in the neoplastic mononuclear cells, but negative in the reactive, surrounding multinucleated giant cells

Back to article page