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Table 2 Prevalence of pre-specified comorbidities

From: The burden of chronic pain for patients with osteoarthritis in Germany: a retrospective cohort study of claims data

Number of patients (%) ICD-10-GM Patients ‘without chronic pain’
n = 158,251
Patients ‘with chronic pain’
n = 80,055
2-yr
baseline
1-yr
follow-up
2-yr
baseline
1-yr
follow-up
Psychiatric disorders
 Major depressive disorder, single episode F32* 28,501 (18.0) 25,426 (16.1) 23,155 (28.9) 21,689 (27.1)
 Major depressive disorder F32*–F33* 31,526 (20.0) 28,930 (18.3) 25,396 (31.7) 24,351 (30.4)
 Major depressive disorder, recurrent F33* 8858 (5.6) 8355 (5.3) 7974 (10.0) 7796 (9.7)
 Phobic anxiety disorders F40* 2326 (1.5) 1858 (1.2) 1692 (2.1) 1396 (1.7)
 Other anxiety disorders F41* 11,767 (7.4) 10,003 (6.3) 8986 (11.2) 7871 (9.8)
 Obsessive-compulsive disorder F42* 579 (0.4) 482 (0.3) 336 (0.4) 303 (0.4)
 Reaction to severe stress, and adjustment disorders F43* 15,912 (10.1) 11,660 (7.4) 10,857 (13.6) 8514 (10.6)
 Somatoform disorders F45* 26,226 (16.6) 20,805 (13.2) 21,377 (26.7) 20,142 (25.2)
 Sleep disorders not due to a substance or known physiological condition F51* 2635 (1.7) 2119 (1.3) 2282 (2.9) 1869 (2.3)
 Abuse of non-psychoactive substances F55* 144 (0.1) 122 (0.1) 281 (0.4) 256 (0.3)
Metabolic disorders
 Type 1 diabetes mellitus E10* 3795 (2.4) 3362 (2.1) 3256 (4.1) 2819 (3.5)
 Type 2 diabetes mellitus E11* 28,745 (18.2) 28,858 (18.2) 20,393 (25.5) 20,274 (25.3)
 Overweight and obesity E66* 31,391 (19.8) 32,445 (20.5) 21,275 (26.6) 21,527 (26.9)
 Disorders of lipoprotein metabolism and other lipidaemias E78* 67,640 (42.7) 65,388 (41.3) 39,901 (49.8) 38,077 (47.6)
 Elevated blood glucose level R73* 3735 (2.4) 3105 (2.0) 2321 (2.9) 2000 (2.5)
Cardiovascular diseases
 Secondary hypertension I15* 2405 (1.5) 1991 (1.3) 1788 (2.2) 1450 (1.8)
 Ischemic heart diseases I20*–I25* 29,228 (18.5) 26,245 (16.6) 21,502 (26.9) 19,446 (24.3)
 Acute myocardial infarction I21* 4801 (3.0) 4092 (2.6) 3760 (4.7) 3251 (4.1)
 Atrial fibrillation and flutter I48* 10,792 (6.8) 11,943 (7.5) 8535 (10.7) 9379 (11.7)
 Non-traumatic intracranial haemorrhage/cerebral infarction I61*–I64* 6664 (4.2) 6506 (4.1) 5207 (6.5) 5183 (6.5)
 Atherosclerosis I70* 13,671 (8.6) 14,287 (9.0) 10,520 (13.1) 10,804 (13.5)
 Aortic aneurysm and dissection I71* 3119 (2.0) 3205 (2.0) 2204 (2.8) 2248 (2.8)
 Phlebitis and thrombophlebitis I80* 7716 (4.9) 7614 (4.8) 5822 (7.3) 5623 (7.0)
Bone and joint conditions
 Gout M10* 8397 (5.3) 7886 (5.0) 5377 (6.7) 5025 (6.3)
 Ankylosing spondylitis M45* 973 (0.6) 1080 (0.7) 849 (1.1) 887 (1.1)
 Other inflammatory spondylopathies M46* 1044 (0.7) 1152 (0.7) 1233 (1.5) 1242 (1.6)
 Synovitis and tenosynovitis M65* 8928 (5.6) 10,091 (6.4) 6229 (7.8) 5885 (7.4)
 Osteoporosis M80*–M81* 12,331 (7.8) 14,768 (9.3) 12,200 (15.2) 14,026 (17.5)
Cancer
 Malignant neoplasms of lip, oral cavity, and pharynx C00*–C14* 547 (0.4) 448 (0.3) 443 (0.6) 388 (0.5)
 Malignant neoplasms of digestive organs C15*–C26* 6135 (3.9) 4652 (2.9) 3976 (5.0) 3356 (4.2)
 Malignant neoplasms of respiratory and intrathoracic organs C30*–C39* 1159 (0.7) 978 (0.6) 1181 (1.5) 1228 (1.5)
 Malignant neoplasms of bone and articular cartilage C40*–C41* 126 (0.1) 127 (0.1) 140 (0.2) 157 (0.2)
 Melanoma and other malignant neoplasms of skin C43*–C44* 16,953 (10.7) 12,862 (8.1) 9566 (12.0) 7156 (8.9)
 Malignant neoplasms of mesothelial and soft tissue C45*–C49* 349 (0.2) 321 (0.2) 294 (0.4) 303 (0.4)
 Malignant neoplasms of breast C50* 5512 (3.5) 4811 (3.0) 3688 (4.6) 3285 (4.1)
 Malignant neoplasms of female genital organs C51*–C58* 1665 (1.1) 1453 (0.9) 1248 (1.6) 1132 (1.4)
 Malignant neoplasms of male genital organs C60*–C63* 5351 (3.4) 5088 (3.2) 2806 (3.5) 2619 (3.3)
 Malignant neoplasms of urinary tract C64*–C68* 2631 (1.7) 2470 (1.6) 1839 (2.3) 1750 (2.2)
 Malignant neoplasms of eye, brain, and other parts of central nervous system C69*–C72* 553 (0.4) 393 (0.3) 382 (0.5) 284 (0.4)
 Malignant neoplasms of thyroid and other endocrine glands C73*–C75* 817 (0.5) 709 (0.5) 553 (0.7) 478 (0.6)
Opioid addiction
 Opioid dependence F11.2 48 (< 0.1) 34 (< 0.1) 190 (0.2) 172 (0.2)
 Opiate substitution Z51.83 71 (< 0.1) 102 (0.1) 267 (0.3) 405 (0.5)
  1. ICD-10-GM International Statistical Classification of Diseases and Related Health Problems, 10th edition, German modification; yr Year