Table 2 Prevalence of pre-specified comorbidities

 Major depressive disorder, single episode

F32*

28,501 (18.0)

25,426 (16.1)

23,155 (28.9)

21,689 (27.1)

 Major depressive disorder

F32*–F33*

31,526 (20.0)

28,930 (18.3)

25,396 (31.7)

24,351 (30.4)

 Major depressive disorder, recurrent

F33*

8858 (5.6)

8355 (5.3)

7974 (10.0)

7796 (9.7)

 Phobic anxiety disorders

F40*

2326 (1.5)

1858 (1.2)

1692 (2.1)

1396 (1.7)

 Other anxiety disorders

F41*

11,767 (7.4)

10,003 (6.3)

8986 (11.2)

7871 (9.8)

 Obsessive-compulsive disorder

F42*

579 (0.4)

482 (0.3)

336 (0.4)

303 (0.4)

 Reaction to severe stress, and adjustment disorders

F43*

15,912 (10.1)

11,660 (7.4)

10,857 (13.6)

8514 (10.6)

 Somatoform disorders

F45*

26,226 (16.6)

20,805 (13.2)

21,377 (26.7)

20,142 (25.2)

 Sleep disorders not due to a substance or known physiological condition

F51*

2635 (1.7)

2119 (1.3)

2282 (2.9)

1869 (2.3)

 Abuse of non-psychoactive substances

F55*

144 (0.1)

122 (0.1)

281 (0.4)

256 (0.3)

 Type 1 diabetes mellitus

E10*

3795 (2.4)

3362 (2.1)

3256 (4.1)

2819 (3.5)

 Type 2 diabetes mellitus

E11*

28,745 (18.2)

28,858 (18.2)

20,393 (25.5)

20,274 (25.3)

 Overweight and obesity

E66*

31,391 (19.8)

32,445 (20.5)

21,275 (26.6)

21,527 (26.9)

 Disorders of lipoprotein metabolism and other lipidaemias

E78*

67,640 (42.7)

65,388 (41.3)

39,901 (49.8)

38,077 (47.6)

 Elevated blood glucose level

R73*

3735 (2.4)

3105 (2.0)

2321 (2.9)

2000 (2.5)

 Secondary hypertension

I15*

2405 (1.5)

1991 (1.3)

1788 (2.2)

1450 (1.8)

 Ischemic heart diseases

I20*–I25*

29,228 (18.5)

26,245 (16.6)

21,502 (26.9)

19,446 (24.3)

 Acute myocardial infarction

I21*

4801 (3.0)

4092 (2.6)

3760 (4.7)

3251 (4.1)

 Atrial fibrillation and flutter

I48*

10,792 (6.8)

11,943 (7.5)

8535 (10.7)

9379 (11.7)

 Non-traumatic intracranial haemorrhage/cerebral infarction

I61*–I64*

6664 (4.2)

6506 (4.1)

5207 (6.5)

5183 (6.5)

 Atherosclerosis

I70*

13,671 (8.6)

14,287 (9.0)

10,520 (13.1)

10,804 (13.5)

 Aortic aneurysm and dissection

I71*

3119 (2.0)

3205 (2.0)

2204 (2.8)

2248 (2.8)

 Phlebitis and thrombophlebitis

I80*

7716 (4.9)

7614 (4.8)

5822 (7.3)

5623 (7.0)

 Gout

M10*

8397 (5.3)

7886 (5.0)

5377 (6.7)

5025 (6.3)

 Ankylosing spondylitis

M45*

973 (0.6)

1080 (0.7)

849 (1.1)

887 (1.1)

 Other inflammatory spondylopathies

M46*

1044 (0.7)

1152 (0.7)

1233 (1.5)

1242 (1.6)

 Synovitis and tenosynovitis

M65*

8928 (5.6)

10,091 (6.4)

6229 (7.8)

5885 (7.4)

 Osteoporosis

M80*–M81*

12,331 (7.8)

14,768 (9.3)

12,200 (15.2)

14,026 (17.5)

 Malignant neoplasms of lip, oral cavity, and pharynx

C00*–C14*

547 (0.4)

448 (0.3)

443 (0.6)

388 (0.5)

 Malignant neoplasms of digestive organs

C15*–C26*

6135 (3.9)

4652 (2.9)

3976 (5.0)

3356 (4.2)

 Malignant neoplasms of respiratory and intrathoracic organs

C30*–C39*

1159 (0.7)

978 (0.6)

1181 (1.5)

1228 (1.5)

 Malignant neoplasms of bone and articular cartilage

C40*–C41*

126 (0.1)

127 (0.1)

140 (0.2)

157 (0.2)

 Melanoma and other malignant neoplasms of skin

C43*–C44*

16,953 (10.7)

12,862 (8.1)

9566 (12.0)

7156 (8.9)

 Malignant neoplasms of mesothelial and soft tissue

C45*–C49*

349 (0.2)

321 (0.2)

294 (0.4)

303 (0.4)

 Malignant neoplasms of breast

C50*

5512 (3.5)

4811 (3.0)

3688 (4.6)

3285 (4.1)

 Malignant neoplasms of female genital organs

C51*–C58*

1665 (1.1)

1453 (0.9)

1248 (1.6)

1132 (1.4)

 Malignant neoplasms of male genital organs

C60*–C63*

5351 (3.4)

5088 (3.2)

2806 (3.5)

2619 (3.3)

 Malignant neoplasms of urinary tract

C64*–C68*

2631 (1.7)

2470 (1.6)

1839 (2.3)

1750 (2.2)

 Malignant neoplasms of eye, brain, and other parts of central nervous system

C69*–C72*

553 (0.4)

393 (0.3)

382 (0.5)

284 (0.4)

 Malignant neoplasms of thyroid and other endocrine glands

C73*–C75*

817 (0.5)

709 (0.5)

553 (0.7)

478 (0.6)

 Opioid dependence

F11.2

48 (< 0.1)

34 (< 0.1)

190 (0.2)

172 (0.2)

 Opiate substitution

Z51.83

71 (< 0.1)

102 (0.1)

267 (0.3)

405 (0.5)