Fig. 4From: Does breaking up prolonged sitting improve cognitive functions in sedentary adults? A mapping review and hypothesis formulation on the potential physiological mechanismsProlonged sitting is viewed as a risk factor for poor cognitive functions because of aberrant physiological changes in the cardiovascular, pulmonary and metabolic systems. Poor cognitive functions might be associated with prolonged sitting during working hours, and negatively affect work productivity as a vicious cycle. Note: ++ denotes established evidence from experimental trials;??? represents a hypothetical link; BDNF – Brain derived neurotrophic factorBack to article page