BMC Musculoskeletal Disorders

Table 5 The Diagnostic capabilities of CRP, IL-6, PCT, NGS and bacterial culture

From: Diagnostic value of next-generation sequencing to detect periprosthetic joint infection

	FP	TP	TN	FN	P	ACC	Sen	P	Spe	P	PPV	NPV	+LR	-LR
CRP	3	10	17	5	< 0.01^*	0.77	0.67	< 0.05^*	0.85	< 0.05^*	0.77	0.77	4.44	0.39
IL-6	1	7	19	8	< 0.01^*	0.74	0.47	< 0.05^*	0.95	> 0.05^*	0.88	0.70	9.33	0.56
PCT	1	10	19	5	< 0.01^*	0.83	0.67	< 0.05^*	0.95	> 0.05^*	0.91	0.79	13.33	0.35
NGS	2	14	18	1	–	0.91	0.93	–	0.90	–	0.88	0.95	9.33	0.07
BC	1	7	19	8	< 0.01^*	0.74	0.47	< 0.05^*	0.95	> 0.05^*	0.88	0.70	9.33	0.56

FP False positive, TP True positive, TN True negative, FN False negative, ACC Accuracy, Sen Sensitivity, Spe Specificity, PPV Positive predictive value, NPV Negative predictive value, +LR Positive likelihood ratio, -LR Negative likelihood ratio, *compared with NGS, BC bacterial culture

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ISSN: 1471-2474

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