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Table 3 Prevalence of IL-21 polymorphisms among controls and RA patients

From: Plasma interleukin-21 levels and genetic variants are associated with susceptibility to rheumatoid arthritis

Polymorphisms

Genotype or Allele

HC (n = 303)

RA (n = 211)

P-value

χ2 value

OR (95% CI)

rs907715 C > T

Genotype

     
 

CC

91 (30)

68 (32)

1

 

ref

 

CT

151 (50)

103 (49)

0.656

0.197

0.912 (0.613 to 1.366)

 

TT

61 (20)

40 (19)

0.613

0.254

0.877 (0.525 to 1.444)

 

CT + TT

212 (70)

143 (68)

0.596

0.280

0.902 (0.622 to 1.319)

 

Allele

     
 

C

333 (55)

239 (57)

1

 

ref

 

T

273 (45)

183 (43)

0.592

0.286

0.934 (0.724 to 1.202)

rs2221903 T > C

      
 

TT

227 (75)

154 (73)

1

 

ref

 

TC

70 (23)

49 (23)

0.883

0.021

1.032 (0.676 to 1.581)

 

CC

6 (2)

8 (4)

0.211

1.561

1.965 (0.658 to 5.779)

 

TC + CC

76 (25)

57 (27)

0.622

0.242

1.106 (0.738 to 1.635)

 

Allele

     
 

T

524 (86)

357 (85)

1

 

ref

 

C

82 (14)

65 (15)

0.399

0.711

1.163 (0.822 to 1.655)

rs2055979 C > A

Genotype

     
 

CC

118 (39)

53 (25)

1

 

ref

 

CA

145 (48)

80 (38)

0.341

0.906

1.228 (0.811 to 1.888)

 

AA

40 (13)

78 (37)

< 0.0001

34.73

4.342 (2.623 to 7.219)

 

CA + AA

185 (61)

158 (75)

0.001

10.71

1.901 (1.301 to 2.796)

 

Allele

     
 

C

381 (63)

186 (44)

1

 

ref

 

A

225 (37)

236 (56)

< 0.0001

35.53

2.149 (1.662 to 2.766)

  1. Note: Data of HC and RA are in the number of subjects (%) format, HC healthy controls, RA rheumatoid arthritis patients