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Table 1 Timeline of the study – outcomes and variables assessed during the trial period

From: Cryoneurolysis for the management of chronic pain in patients with knee osteoarthritis; a double-blinded randomized controlled sham trial

Timepoint Study period
Enrolment Allocation Post-allocation Follow-up
-4w -1w 0w 2w 10w na 24w 48w 96w
Enrolment:
 Eligibility screening X         
 Informed consent X         
 Genicular nerve block   X        
 Allocation    X       
Interventions:
 Cryoeurolysis (CRYO)    X       
 Sham treatment (SHAM)    X       
 GLA:D (SHAM & CRYO)     X X     
Assessments:
 Pain    X X   X X X X
 Functional performance    X X   X X X X
 KOOS    X X   X X X X
 EQ5D    X X   X X X X
 Adverse effects    X X   X X X X
 Analgesics    X X   X X X X
  1. w Weeks, na Not applicable (GLA:D start time may vary)