Fig. 4From: The attenuation of insulin-like growth factor signaling may be responsible for relative reduction in matrix synthesis in degenerated areas of osteoarthritic cartilageConcentration of IGF-related proteins in OA cartilage. Cartilage was obtained from OA knees at macroscopically preserved areas (Preserved) and degenerated areas (Degenerated) in pairs. Proteins were extracted, and concentrations of indicated protein were determined and compared between the preserved and degenerated areas. The findings for of IGF1R (a), IRS1 (b), IGFBP-1 (c), IGFBP-3 (d) and IGFBP-6 (e) are shown. Values are normalized by the total protein concentration of the extract. Results are the mean + SE of 20 samples. *, P < 0.05 and **, P < 0.01Back to article page