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Fig. 6 | BMC Musculoskeletal Disorders

Fig. 6

From: Compressive mechanical stress enhances susceptibility to interleukin-1 by increasing interleukin-1 receptor expression in 3D-cultured ATDC5 cells

Fig. 6

TRPV4 channel regulation in 3D-cultured constructs. TRPV4 channel regulation modulated mRNA levels of ADAMTS4 and IL-1R in 3D-cultured constructs under compressive stress. TRPV4 agonist suppressed upregulation of ADAMTS4 and IL-1R mRNAs by 40 kPa of cyclic compressive stress, whereas TRPV4 antagonist rather accelerated these mRNA expressions. Such change in both mRNA expressions were not induced by 20 kPa of cyclic compressive loading. Values are given as mean ± SD (n = 6 each). *P < 0.05

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BMC Musculoskeletal Disorders

ISSN: 1471-2474

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