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Fig. 3 | BMC Musculoskeletal Disorders

Fig. 3

From: Compressive mechanical stress enhances susceptibility to interleukin-1 by increasing interleukin-1 receptor expression in 3D-cultured ATDC5 cells

Fig. 3

Effects of cyclic compressive loading on 3D-cultured constructs. a) Temporal changes in mRNA expression levels of MMP-3, ADAMTS4 and IL-1R were analyzed for 12 h (n = 6 each). All mRNA expression levels were upregulated at 6 h after compressive loading for 3 h. b) The mRNA expression levels of ADAMTS4, MMP3, IL-6, and IL-1R were all increased by 40 kPa compressive loading at 6 h, whereas these mRNA expressions were not stimulated by 20 kPa loading. IL-1β expression level was unchanged after compressive loading. Values are given as mean ± SD (n = 6 each). *P < 0.05

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BMC Musculoskeletal Disorders

ISSN: 1471-2474

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