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Table 3 Factors associated with a clinically meaningful placebo response

From: Predictors of a placebo response in patients with hand osteoarthritis: post-hoc analysis of two randomized controlled trials

 

Univariate

Multivariate

Variables

OR

95% CI

P value

OR

95% CI

P value

Age

1.031

0.987–1.077

0.164

1.039

0.987–1.094

0.141

Gender (female)

5.235

0.636–43.068

0.124

10.552

0.931–119.633

0.057

Weight, kg

1.011

0.970–1.053

0.603

   

Height, cm

0.958

0.902–1.016

0.152

1.010

0.934–1.091

0.811

BMI

1.104

0.979–1.245

0.108

1.104

0.969–1.258

0.136

Ds duration

1.017

0.944–1.097

0.655

   

AUSCAN-Pain

1.028

1.010–1.046

0.002

1.054

1.019–1.089

0.002

AUSCAN-Function

1.021

1.005–1.037

0.010

0.974

0.947–1.001

0.058

AUSCAN-Stiffness

1.028

0.998–1.027

0.423

   

Physician global assessment

1.025

0.996–1.054

0.088

1.018

0.986–1.052

0.270

Patient global assessment

1.015

0.995–1.035

0.137

0.998

0.972–1.024

0.872

Tender JC

1.028

0.961–1.098

0.423

   

Swollen JC

0.914

0.762–1.097

0.334

   

CRP

0.444

0.08–2.474

0.355

   

ESR

1.011

0.978–1.045

0.531

   
  1. Multivariate logistic regression was performed. Variables that showed association (p < 0.2) in the univariable analysis were included in the multivariable analysis. AUSCAN Australian/Canadian Osteoarthritis Hand Index, BMI Body mass index, CI Confidence interval, CRP C-reactive protein, Ds Disease, ESR Erythrocyte sedimentation rate, JC Joint count, NSAID Non-steroidal anti-inflammatory drug, OR Odds ratio, OA Osteoarthritis.