Fig. 2

Placebo response. a Change in AUSCAN-pain at 4 weeks from the baseline in 102 patients in RCT 1 and 41 patients in RCT 2 were depicted. Red dotted line marks the clinically meaningful response. b Correlation between pain, stiffness, and function at baseline and placebo responses in 143 patients with hand osteoarthritis. Scatterplot represents the relation between the change in pain, stiffness and function and their respective baseline value. Correlations were examined by using Pearson’s correlation analysis