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Table 1 Characteristics of the index fragility fracture cohort

From: Fragility fracture identifies patients at imminent risk for subsequent fracture: real-world retrospective database study in Ontario, Canada

Characteristic

n (%)a

Total number of patients in cohort

115,776

Sex

 Women

83,690 (72.3)

 Men

32,086 (27.7)

Age (years)

 Median (IQR)

81 (74–87)

 Mean (SD)

80.4 (8.3)

 66–70

17,998 (15.5)

 71–75

17,847 (15.4)

 76–80

20,596 (17.8)

 81–85

24,119 (20.8)

  ≥ 86

35,216 (30.4)

Index fracture by siteb

 Hip

31,613 (27.3)

 Wrist (distal radius, or both distal radius and ulna)

17,859 (15.4)

 Clavicle/ribs/sternum

14,559 (12.6)

 Humerus

13,237 (11.4)

 Tibia/fibula/knee (including medial and lateral malleolus)

10,894 (9.4)

 Pelvis

8328 (7.2)

 Vertebral (clinical)

7721 (6.7)

 Radius/ulna (proximal, midshaft, or distal ulna only)

4828 (4.2)

 Multisite

3735 (3.2)

 Femur

3002 (2.6)

Index fracture at any site by yearb

 2011

25,154

 2012

26,045

 2013

27,969

 2014

29,385

 2015b

7223

Index fragility fracture treatment location

 Urban

103,720 (89.6)

 Rural

10,626 (9.2)

 Missing

1430 (1.2)

Respiratory conditionsc

 Asthma

17,538 (15.1)

 COPD

33,485 (28.9)

Inflammatory conditionsc

 RA

4459 (3.9)

 Psoriasis

8076 (7.0)

 SPA

5084 (4.4)

 Osteoarthritis

88,223 (76.2)

Cancerc

8390 (7.2)

Chronic kidney diseasec

13,757 (11.9)

Diabetesc

35,434 (30.6)

Vascular eventsc

 MI

8175 (7.1)

 Stroke or Cerebrovascular Events

35,030 (30.3)

Dementiac

24,092 (20.8)

OP treatmentd

 Any OP treatment

32,757 (28.3)

 Bisphosphonate

29,030 (25.1)

 Denosumab

1578 (1.4)

 HRT

3597 (3.1)

 Raloxifene

656 (0.6)

 Teriparatide

0 (0)

Steroid used

3340 (2.9)

Opioid used

34,834 (30.1)

  1. Abbreviations: COPD chronic obstructive pulmonary disease, HRT hormone replacement therapy, IQR interquartile range, MI myocardial infarction, OP osteoporosis, RA rheumatoid arthritis, SD standard deviation, SPA spondyloarthritis
  2. aValues reported as n (%) unless otherwise indicated; percent of total cohort (N = 115,776)
  3. bIndex fragility fracture cases from January 1, 2011 to March 31, 2015
  4. cTime frame for cancer was within 5 years prior to index date and for all other comorbidities any time prior to index date
  5. dDispensed within one year prior to index fracture; assessed based on public coverage