Table 3 The main results of all the RCTs investigating the effectiveness of TXA after ACLR

Felli et al. [9]

IV

IV of TXA administration reduced hemarthrosis and the amount of drainage blood.

Karaaslan et al. [10]

IV

IV of TXA reduced the amount of postoperative hemarthrosis and reduced pain.

Hetsroni et al. [15]

IV

IV of TXA reduced drained blood volume on postoperative day 1 and hemarthrosis up to postoperative day 15 but did not improve clinical outcomes at 3 months.

Chiang et al. [11]

IA

IA of TXA could significantly reduce postoperative intra-articular bleeding in the first 24 h, and decrease pain and the grade of hemarthrosis in the early postoperative period.