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Table 1 Eligibility Criteria

From: Study protocol: randomized controlled trial of opioid-free vs. traditional perioperative analgesia in elective orthopedic surgery

Inclusion Criteria:
 • Patient is scheduled to undergo one of the following procedures:
   • Primary single-level or two-level ACDF or ACDA for degenerative disease
   • Primary 1st CMC arthroplasty
   • Primary Hallux Valgus or Hallux Rigidus correction
   • Diagnostic knee arthroscopy +/− meniscal debridement
   • Elective primary total shoulder or reverse total shoulder arthroplasty
   • Primary total hip arthroplasty
Exclusion Criteria:
• Revision surgery for one of the study-specific procedures
• Chronic opioid therapy – per investigator discretion
• Significant liver disease – (NOTE: Patients with a history of liver disease had a hepatic panel drawn that was reviewed by the study investigator to assess if the values were within acceptable limits for inclusion in the study)
• Fracture or soft tissue injury
• Sickle cell disease
• Workers compensation
• Alcohol dependence
• Contra-indication to regional anesthesia
• History of gastrointestinal (GI) bleeding or peptic ulcer
• History of bleeding problems
• Patients taking anticoagulants, not including aspirin (only applied to Randomized portion of study. These patients could still participate in Observational Control Group)
• Renal insufficiency – Creatinine clearance less than 30 mL/min (only applied to patients having surgery requiring NSAID treatment)
• Hammertoe in isolation (Hallux Valgus/Rigidus exclusion only)
• Concomitant meniscal repair or microfracture (Knee Arthroscopy exclusion only)
• Ineligible for spinal anesthesia (THA exclusion only)
• Previous ipsilateral hip surgery, not including hip scope (THA exclusion only)
• Allergy to non-steroidal anti-inflammatory medications (NSAIDs)