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Fig. 4 | BMC Musculoskeletal Disorders

Fig. 4

From: Topical co‐administration of zoledronate with recombinant human bone morphogenetic protein-2 can induce and maintain bone formation in the bone marrow environment

Fig. 4

Quantitative evaluation of H&E sections and Masson’s Trichrome sections of the of the left distal femurs of rabbits in each group at 3 and 6 weeks after implantation. The columns and bars represent the means and standard deviations (n = 7), respectively. At 3 weeks after implantation, the groups containing rh-BMP-2 (Group 2 or 4) showed greater areas of new bone formation than the other groups (P < 0.05). However, at 6 weeks after implantation, only the group (Group 4) that involved the combination usage of both rh-BMP-2 and ZOL still showed areas of newly formed bone (P < 0.05). *: P < 0.05. Statistical differences between groups were determined using a one-way analysis of variance with Bonferroni’s multiple comparison test. Note: H&E, Hematoxylin-Eosin; MT, Masson Trichrome; rh-BMP-2, recombinant human bone morphogenetic protein 2; ZOL, zoledronate

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BMC Musculoskeletal Disorders

ISSN: 1471-2474

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