Table 1 Clinical characteristics of the fracture cohort and non-fracture cohorts
Clinical Characteristics | Fracture cohort n (%) | Non-fracture cohort n (%) |
|---|---|---|
Total number of patients | 101,773 | 101,773 |
Sex | ||
 Female | 74,557 (73.3%) | 74,557 (73.3%) |
 Male | 27,216 (26.7%) | 27,216 (26.7%) |
Age | ||
 Mean ± SDa | 80.25 ± 8.37* | 80.33 ± 8.75* |
 Median (IQR)a | 81 (73–87) | 81 (73–87) |
 66–70 years | 16,672 (16.4%) | 16,672 (16.4%) |
 71–75 years | 15,996 (15.7%) | 15,996 (15.7%) |
 76–80 years | 17,952 (17.6%) | 17,952 (17.6%) |
 81–85 years | 20,584 (20.2%) | 20,584 (20.2%) |
 ≥86 years | 30,569 (30.0%) | 30,569 (30.0%) |
Urban Residence | 89,696 (88.1%) | 89,696 (88.1%) |
Respiratory conditionsb | ||
 Asthma | 13,113 (12.9%) | 13,113 (12.9%) |
 COPD | 25,991 (25.5%) | 25,991 (25.5%) |
Inflammatory conditionsb | ||
 Rheumatoid arthritis | 2208 (2.2%) | 2208 (2.2%) |
 Psoriasis | 4985 (4.9%) | 4985 (4.9%) |
 Spondyloarthritis | 2432 (2.4%) | 2432 (2.4%) |
Cancerb | 5166 (5.1%) | 5166 (5.1%) |
Chronic kidney diseaseb | 8909 (8.8%) | 8909 (8.8%) |
Diabetesb | 29,074 (28.6%) | 29,074 (28.6%) |
Vascular eventsb | ||
 Myocardial infarction | 4549 (4.5%) | 4549 (4.5%) |
 Stroke or cerebrovascular events | 28,015 (27.5%) | 28,015 (27.5%) |
Osteoarthritisb | 77,526 (76.2%) | 77,526 (76.2%) |
Dementiab | 18,359 (18.0%) | 18,359 (18.0%) |
Osteoporosis treatment type within 1 year priora,c | ||
 Any treatment | 28,974 (28.5%)** | 21,179 (20.8%)** |
 Denosumab | 1383 (1.4%)** | 1088 (1.1%)** |
 Bisphosphonate | 25,626 (25.2%)** | 17,720 (17.4%)** |
 Raloxifene | 599 (0.6%)** | 465 (0.5%)** |
 HRT | 3259 (3.2%) | 3312 (3.3%) |
Index fracture by sitea,d | ||
 Hip | 26,963 (26.5%) | – |
 Wrist | 16,467 (16.2%) | – |
 Humerus | 11,756 (11.6%) | – |
 Ribs | 10,247 (10.1%) | – |
 Tibia/fibula/knee | 9859 (9.7%) | – |
 Pelvis | 7209 (7.1%) | – |
 Vertebral | 6595 (6.5%) | – |
 Radius/ulna | 4377 (4.3%) | – |
 Multisite | 3299 (3.2%) | – |
 Femur | 2618 (2.6%) | – |
 Clavicle/sternum | 2383 (2.3%) |  |
 Any site | 101,773 (100%) |  |
Second fracture by sitea,d | ||
 Hip | 4956 (4.9%) | – |
 Wrist | 2002 (2.0%) | – |
 Humerus | 1814 (1.8%) | – |
 Pelvis | 1722 (1.7%) | – |
 Ribs | 1647 (1.6%) | – |
 Vertebral | 1590 (1.6%) | – |
 Multisite | 1326 (1.3%) | – |
 Tibia/fibula/knee | 1164 (1.1%) | – |
 Radius/ulna | 650 (0.6%) | – |
 Femur | 620 (0.6%) | – |
 Clavicle/sternum | 467 (0.5%) |  |
 Any site | 17,958 (17.6%) |  |