Table 1 Comparison of clinical data of the renal tubular acidification dysfunction group and the normal function group (X±S)

Sex (male/female)

13/28

8/26

0.432 (χ²)

Medical history (y)

0.25 (1, 5.5)

0.33 (1, 5)

0.881 (Non-parametric)

Age, y

61.1 ± 12.0

56.8 ± 11.0

0.116

BMI, kg/m²

24.2 ± 4.85

24.74 ± 3.84

0.602

Albumin, g/L

41.24 ± 3.86

40.79 ± 3.54

0.604

Albumin-corrected serum calcium, mmol/L

2.80 ± 0.39

2.84 ± 0.31

0.635

Serum phosphate, mmol/L

0.69 ± 0.17

0.79 ± 0.18

0.017

Serum potassium, mmol/L

3.85 ± 0.50

4.08 ± 0.51

0.061

Serum chloride (mmol/L)

107.55 ± 3.45

107.23 ± 3.99

0.717

Serum sodium (mmol/L)

141.06 ± 2.70

142.24 ± 1.71

0.062

Serum magnesium (mmol/L)

0.83 ± 0.11

0.86 ± 0.07

0.220

Serum creatinine, umol/L

58 (47.5, 73)

58 (42.75, 73.25)

0.447 (Non-parametric)

AkP (U/L)

125 (91.5, 231.5)

103.5 (67, 157.75)

0.075 (Non-parametric)

PTH (pmol/L)

59.4 (24.65, 130)

36.1 (17.17, 64.02)

0.061 (Non-parametric)

25OHD (nmol/L)

34.5 (21.4, 64.02)

25.5 (20.45, 32.66)

0.020 (Non-parametric)

Urine PH (4.5-6.5)

6.67±0.45

5.78±0.42

0.000

Urine HCO3^-(0-12.44mmol/L)

5.50 (3.35, 10.90)

4.50 (2.87, 5.90)

0.231 (Non-parametric)

Urine TA (9.57-150mmol/L)

4.45 ± 2.83

11.91 ± 4.39

0.000

Urine NH4⁺(25.84-200mmol/L)

16.48 ± 5.57

25.62 ± 5.89

0.000

Blood gas PH (7.35-7.45)

7.40 ± 0.28

7.40 ± 0.21

0.266

PCO2 (mmHg)

36.76 ± 5.12

37.51 ± 4.84

0.519

HCO3-(mmol/L)

23.20 ± 3.15

23.87 ± 2.63

0.327

BE (mmol/L)

-1.80 (-3.3, 0.82)

-0.77 (-1.92, 1.00)

0.165 (Non-parametric)

Urinary calcium, (mmol/24h)

8.30 ± 3.30

7.98 ± 3.64

0.280

Urinary phosphate, (mmol/24h)

18.8 ± 7.34

20.4 ± 8.34

0.389

Urinary potassium, (mmol/24h)

18.65 ± 7.11

20.40 ± 8.34

0.331

Urine sodium (mmol/24h)

138.46 (93.01, 205.75)

197.6 (157.59, 228.51)

0.161 (Non-parametric)

Urine magnesium (mmol/24h)

2.85 (1.84, 3.63)

2.7 (2.19, 3.48)

0.898 (Non-parametric)

OC (ng/ml)

60.06 (29.49, 125.25)

59.61 (33.58, 131.30)

0.903 (Non-parametric)

CTX (ng/ml)

0.99 (0.65, 1.86)

1.18 (0.80, 2.49)

0.225 (Non-parametric)

PINP (ng/ml)

70 (45.28, 125.25)

74.28 (41.09, 103.80)

0.709 (Non-parametric)

Kidney stones (with/without)

19/22

12/22

0.333 (χ²)

Fracture (with/without)

13/28

10/24

0.830 (χ²)