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Table 3 The baseline characteristics of survivors and non-survivors

From: Serum osteocalcin level is associated with the mortality in Chinese patients with Fibrodysplasia ossificans progressiva aged ≤18 years at diagnosis

FOP patients ≤18y >18y Total
survivors
(group A)
non-survivors (group B) survivors
(group C)
non-survivors (group D)
Cases 40(88.9%) 5(11.1%) 16(80%) 4(20%) 65
Gender ratio (M/F) 21/19 1/4 6/10 2/2 30/35
Age at diagnose (years) 9.6 ± 5.0 11.6 ± 6.3 24.4 ± 7.1 ** 25.5 ± 2.4 ** 14.4 ± 8.8
Age of onset 3.6 ± 2.9 2.3 ± 2.3 4.6 ± 4.4 3.4 ± 2.2 4.2 ± 3.9
Age at death (years) 17.4 ± 7.2 29.5 ± 2.9 22.8 ± 8.9
OC (ng/mL) 87.7 ± 32.7 48.7 ± 15.5** 34.7 ± 19.8** 26.8 ± 16.1** 67.9 ± 37.8
Ca (mmol/L) 2.32 ± 0.2 2.34 ± 0.07 2.32 ± 0.08 2.24 ± 0.05 2.32 ± 0.15
P (mmol/L) 1.58 ± 0.25 1.42 ± 0.15 1.23 ± 0.3** 1.02 ± 0.21** 1.45 ± 0.31
PTH (pg/mL) 63.3 ± 487.4 53.2 ± 25.9 81.5 ± 37.7 71.9 ± 14.3 67.5 ± 42.8
ALP (IU/L) 244.0 ± 121.1 128.2 ± 85.0* 121.9 ± 78.6** 82.2 ± 24.9* 192.3 ± 121.9
ESR (mm/hr) 7.9 ± 5.2 9.4 ± 8.7 10.2 ± 9.2 9.25 ± 5.6 8.6 ± 7.8
ALT (U/L) 14.9 ± 7.2 10.6 ± 3.4 15.0 ± 10.6 16.7 ± 13.2 14.6 ± 8.0
AST (U/L) 24.6 ± 9.7 23.1 ± 6.0 25.3 ± 10.9 19.57 ± 12.7 24.3 ± 13.3
Cr (umol/L) 38.0 ± 14.3 31.0 ± 5.2 46.8 ± 14.0 43.7 ± 11.3 39.4 ± 14.0
BUN (mmol/L) 2.0–5.8 1.7–7.2 2.9–6.3 2.2–5.3 1.7–7.2
  1. Compared with group A, *P < 0.05, **P < 0.01; Compared with group B, P < 0.05, P < 0.01;
  2. OC osteocalcin, Ca total serum calcium, P phosphorus, PTH parathyroid hormone, ALP alkaline phosphatase, ESR erythrocyte sedimentation rate, CRP C-reactive protein, ALT alanine aminotransferase, AST aspartate aminotransferase, Cr creatinine, BUN blood urea nitrogen