Author | Exposure | Results |
---|---|---|
CRP | ||
Gebhardt et al., 2006 [23] | NSLBP vs. controls VAS (last 24 h); Functional back capacity score | No significant differences in geometric mean hsCRP levels based on log-transformation between NSLBP and control at baseline (MD = 0.1 95%CI −0.6 to 0.7)). No difference mean change from baseline to 6 months in the NSLBP group (MD = 0.1 95% CI − 0.6 to 0.7). |
Sturmer et al., 2005 [28] | NSLBP vs. controls VAS (last 24 h) | There was no difference in hsCRP concentration between pain (> 4.5) compared to low values of pain (≤2.3) (OR = 0.87 (95% CI 0.25 to 3.0)) after adjusting for BMI, age, smoking, alcohol consumption, diabetes and analgesic drugs. |
Klyne et al., 2017 [25] | NSLBP vs. controls VAS | CRP was higher in NSLBP participants than controls (p = 0.003). Between the three groups, CRP levels were higher in those with high-pain (VAS ≥4) than low-pain (VAS < 4) groups (p = 0.005) and controls (post-hoc: p = 0.005). Linear and quantile analysis revealed significant positive associations between CRP pain intensity (β = 0.17, 95%CI 0.03 to 0.31) |
Klyne et al., 2018 [26] | Recovered, partially recovered, unrecovered VAS RMDQ | CRP levels between the unrecovered group and recovered group (β = 2.47 (95% CI 1.09 to 3.85) and between the partially recovered and recovered group (β = 1.80 (95% CI 0.39 to 3.21) were significant. |
IL-6 | ||
Heffner et al., 2011 [24] | NSLBP vs. controls PSQI MPQ-SF | There was no difference in IL-6 levels between NSLBP and control (MD = − 0.1 95%CI − 0.6 to 0.4) IL-6 levels were also associated with higher MPQ-SF affective pain ratings (r = 0.46, p = 0.02). Regression analysis showed IL-6 levels were not significantly related to pain (β =1.06; p = 0.14). |
Klyne et al., 2017 [25] | NSLBP vs. controls VAS | There was no significant difference between NSLBP and controls for IL-6 (p = 0.141). Between the three groups IL-6 was higher in high-pain (VAS ≥ 4) than the low-pain group (VAS < 4) (p = 0.034), but not the control group (p = 0.114). |
Klyne et al., 2018 [26] | Recovered, partially recovered, unrecovered. VAS RMDQ | No group or session differences were found for IL-6 with results representing narrow confidence intervals. |
IL-1 | ||
Luchting et al., 2016 [27] | NSLBP vs. controls | Increased serum levels of IL-1β in patients with neuropathic pain (p < 0.05) was found but not in NSLBP (p > 0.05). |
Klyne et al., 2017 [25] | NSLBP vs. controls VAS | There was no difference in IL-β levels between NSLBP and control (MD = − 0.1 95%CI − 0.6 to 0.4) Between the three groups, there was no difference IL-1β. Linear and quantile analysis revealed significant positive associations between IL-β 80th and 95% quartiles with pain magnification (β = 0.11, 95%CI 0.03 to 0.19) and (β = 0.11, 95%CI 0.03 to 0.18). |
Klyne et al., 2018 [26] | Recovered, partially recovered, unrecovered. VAS RMDQ | No group or session differences were found for IL-1β with results representing narrow confidence intervals. |
TNF-α | ||
Wang et al., 2010 [29] | NSLBP vs. controls VAS (last 24 h and past week) RMDQ | Median TNF-α serum levels of patients with chronic NSLBP (2.51 pg/mL) and NSLBP with depression (2.58 pg/mL) were significantly higher than age matched controls (0.1 pg/mL; p = 0.004 for NSLBP; p = 0.002 for NSLBP + depression). No significant associations were found between TNF-α levels and pain intensity. |
Wang et al., 2008 [30] | NSLBP vs. controls VAS RMDQ | Significant difference between groups in percentage of subjects with elevated TNF-α (> 2 pg/mL) at all four time points (baseline OR = 9.5; 95%CI 5.0 to 18.2), (180 days OR = 5.7; 95%CI 3.0 to 11.0). No significant association was found between levels of TNF-α with pain and disability scores. |
Klyne et al., 2017 [25] | NSLBP vs. controls VAS | There was no significant difference between NSLBP and controls for TNF-α (p = 0.174). There was no difference in TNF-α between the three groups. Linear regression revealed significant an association between TNF-α with pain rumification (β = − 0.20, 95%CI − 0.37 to − 0.02). |
Klyne et al., 2018 [26] | Recovered, partially recovered, VAS RMDQ– | TNF-α was lower in the recovered group at both time-points than the other groups. TNF-α was different between the unrecovered vs. recovered groups (β = − 0.68;95% CI − 1.08 to − 0.27) and partially recovery versus recovered (β = − 0.42; 95% CI− 0.72 to − 0.12). |
Other | ||
Luchting et al., 2016 [27] | NSLBP vs. controls | P2RX7 mRNA expression increased in patients with neuropathic pain to controls (MD = -0.6 95%CI − 0.9 to − 0.3), but not in patients NSLBP compared to controls (MD = -0.1 95%CI − 0.4 to 0.2). |