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Table 1 Data extraction table

From: A systematic review of inflammatory cells and markers in human tendinopathy

Study

Sample size

Presentation of tendinopathy

Additional factors associated with inflammationa

Site

QA

Method (cells)

Inflammatory cell + b

Cell types

Method (markers)

Inflammatory markers

Campbell 2014 [13]

18

Partial tear

Mean number of steroid injections 1.5

RC

8/11

IHC

100%

MP

qPCR

IL-21 receptor protein and mRNA

Cetti 2003 [14]

60

Rupture

High activity level

AT

8/11

IHC

100%

NP

n/a

n/a

Dakin 2015 [15]

32

Pain or partial tear

n/a

RC

9/11

IHC

100%

MP

n/a

n/a

Dakin 2017 [16]

17

Pain or rupture

n/a

AT

7/11

IHC

100%

MP

qPCR, IF

IL-8 mRNA, protein

Hackett 2016 [17]

39

Calcific

n/a

RC

9/11

IHC

100%

MP, TC, MC

n/a

n/a

Klatte-schulz 2018 [18]

26

Pain or ruptures

High activity level

AT

8/11

IHC

88%

MP, NS

qPCR

IL-6, IL-10, IL-33. IL1B, TNFa, TGFB1, COX-2

Kragsnaes 2014 [19]

50

Pain

44% received steroid injection

AT

9/11

IHC

96%

MP, TC, MC, NKC

n/a

n/a

Matthews 2006 [20]

38

Rupture

Mean number of steroid injections 1.8

RC

8/11

IHC

100%

MP, TC, MC

n/a

n/a

Millar 2010 [21]

20

Pain or partial tear

High activity level with mean number of 1.5 steroid injections

RC

8/11

IHC

100%

MP, TC, MC

n/a

n/a

Millar 2012 [22]

15

Pain or partial tear

High activity level with mean number of 1.6 steroid injections

RC

8/11

IHC

100%

MP, TC, MC

IHC, qPCR

IL-6, IL-8 protein and mRNA

Millar 2016 [23]

10

Pain or partial tear

High activity level with mean number of 1.7 steroid injections

RC

7/11

IHC

100%

MP, TC, MC

qPCR

IL-17A mRNA

Mosca 2017 [24]

13

Pain

n/a

RC

9/11

IHC

100%

MP

qPCR

IL-33 protein

Pecina 2010 [25]

34

Pain

n/a

PT

8/11

IHC

100%

NS

n/a

n/a

Schubert 2005 [26]

10

Pain or rupture

40% received steroid injection

AT

6/11

IHC

80%

MP, TC, GC

n/a

n/a

Scott 2008 [27]

22

Pain

n/a

PT

7/11

IHC

23%

MC

n/a

n/a

Thankam 2017 [28]

15

Pain or partial tear

Glenohumeral arthritis observed

LHBT

7/11

IHC

27%

MP, NP

n/a

n/a

Åström 1995 [29]

145

Pain or partial tear

n/a

AT

6/11

H&E

9%

NS

n/a

n/a

Gaida 2012 [30]

23

Pain

n/a

AT

8/11

H&E

0%

/

ELISA

TNFa protein

Gumina 2006 [31]

38

Partial tear

n/a

RC

10/11

H&E

100%

MP, LC

n/a

n/a

Kannus 1991 [32]

891

Rupture

n/a

Various

9/11

H&E

0%

/

n/a

n/a

Khan 1996 [33]

28

Pain

n/a

PT

9/11

H&E

0%

/

n/a

n/a

Lian 2007 [34]

23

Pain

n/a

PT

7/11

H&E

0%

/

n/a

n/a

Ljung 1999 [35]

6

Pain

n/a

ECRB

6/11

H&E

0%

/

n/a

n/a

Longo 2008 [36]

88

Rupture

n/a

RC

8/11

H&E

0%

/

n/a

n/a

Longo 2009 [37]

51

Rupture

n/a

LHBT

8/11

H&E

0%

/

n/a

n/a

Popp 1997 [38]

11

Pain

n/a

PT

5/11

H&E

0%

/

n/a

n/a

Potter 1995 [39]

20

Pain

n/a

ECRB

7/11

H&E

0%

/

n/a

n/a

Rolf 1997 [40]

60

Pain

72% received NSAIDs and 27% received steroid injection

AT

8/11

H&E

0%

/

n/a

n/a

Rolf 2017 [41]

20

Rupture

Sign of infection in 40% (bacteria), 5% received steroid injection

7/20 high activity level

AT

9/11

H&E

50%

MP, TC, MC

n/a

n/a

Shalabi 2002 [42]

15

Pain

n/a

AT

8/11.

H&E

0%

/

n/a

n/a

Singaraju 2008 [43]

6

Pain

n/a

LHBT

6/11

H&E

100%

NS

n/a

n/a

Tillander 2002 [44]

23

Pain, partial tear or rupture

n/a

RC

6/11.

H&E

0%

/

n/a

n/a

Zabrzynski 2017 [45]

35

Pain

n/a

LHBT

9/11

H&E

9%

NS

n/a

n/a

Ackermann 2013 [46]

18

Rupture

n/a

AT

7/11

n/a

n/a

/

MD

IL-12, IL-17, IL-1B, IL-6, IL-8, IL-10 protein

Alfredson 2000 [47]

4

Pain

n/a

ECRB

6/11

n/a

n/a

/

MD

PGE2

Alfredson 2003 [48]

10

Pain

n/a

AT

7/11

n/a

n/a

/

MA

IL 1–6, 10–15 mRNA

Alfredson 2001 [49]

10

Pain

n/a

PT

7/11

H&E

n/a

NS

MD

PGE2

Alfredsson 1999 [50]

5

Pain

n/a

AT

6/11

n/a

n/a

/

MD

PGE2

Chaudhury 2016 [51]

16

Pain

n/a

RC

8/11

n/a

n/a

/

qPCR

IL-8 mRNA

Dean 2015 [52]

9

Pain

100% received steroid injection

RC

7/11

n/a

n/a

/

qPCR

TNF-a, IL-1b mRNA

Fabis 2014 [53]

9

Rupture

n/a

RC

7/11

n/a

n/a

/

qPCR

TNF-a, IL-10 mRNA

Fu 2002 [54]

11

Pain

n/a

PT

7/11

n/a

0%

/

IHC, WB

COX-2, TGF-b protein, PGE2

Gilmer 2015 [55]

62

Pain or partial tear

n/a

LHBT

9/11

H&E

n/a

NS

n/a

n/a

Jelinsky 2011 [56]

23

Pain, tear, or rupture

52% received steroid injection

Various

8/11

n/a

0%

/

qPCR

IL13A2, FGFR1, FGFR2, IL-17D mRNA

Jozsa 1980 [57]

120

Rupture or calcific

n/a

Various

8/11

H&E

n/a

NS

n/a

n/a

Legerlotz 2012 [58]

20

Pain or rupture

n/a

AT PT

7/11

n/a

n/a

/

qPCR

COX-2, IL6, IL6R mRNA

Millar 2015 [59]

17

Pain or partial tear

n/a

RC

8/11

n/a

n/a

/

qPCR

IL-33 mRNA

Pingel 2012 [60]

14

Pain

100% received steroid injection

AT

8/11

n/a

n/a

/

qPCR

COX-1, IL-1R, TGF-B1, bFGF mRNA

Pingel 2013 [61]

27

Pain

100% received steroid injection

AT

8/11

n/a

n/a

/

qPCR

IL-1b, IL-6, IL-10, COX-2, TGF-b, TNF-a mRNA

Robertson 2012 [62]

35

Partial tear or rupture

n/a

RC

8/11

n/a

n/a

/

qPCR

IL-1b, IL-6, TNF-a, COX-2 mRNA

Shindle 2011 [63]

24

Partial tear or Rupture

Joint inflammation

RC

8/11

n/a

n/a

/

qPCR

IL-1b, IL-6, COX-2, TNF-a mRNA

Takeuchi 2001 [64]

7

Calcific

n/a

RC

5/11

IHC

n/a

MP

n/a

n/a

Waugh 2015 [65]

10

Pain

n/a

AT PT

7/11

n/a

n/a

/

MD

IL-1b, IL-2, IL-6,IL-8, IL-10 protein

  1. Table sorted by method used to detect the presence of inflammatory cells
  2. Locations: AT Achilles tendon, PT patellar tendon, RC rotator cuff tendon, QT Quadriceps tendon, LHBT Long head biceps tendon, ECRB extensor carpi radialis brevis tendon, CF Common flexor tendon, CE Common extensor tendon, various (studies with specimens from more than 3 locations)
  3. Cells: MP Macrophages, MC Mast-cells, TC T-cells, LC Lymphocytes, NP Neutrophils, GC granulocytes, NKC NK-cells, NS not specified
  4. Detection method: H&E Hematoxylin & Eosin, qPCR quantitative polymerase chain reaction, IHC immunohistochemistry, IF immunofluorescence, MD Micro-dialysis, WB western blot, EIA enzyme immunoassay, ELISA Enzyme-Linked ImmunoSorbent Assay
  5. a Additional factors associated with inflammation description on patient subgroup and previous treatments
  6. bInflammatory cell + refers to the percentage of specimens showing at least 1 kind of inflammatory cells, regardless of typing
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BMC Musculoskeletal Disorders

ISSN: 1471-2474

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