Skip to main content
Fig. 5 | BMC Musculoskeletal Disorders

Fig. 5

From: Polyphyllin VII attenuated RANKL-induced osteoclast differentiation via inhibiting of TRAF6/c-Src/PI3K pathway and ROS production

Fig. 5

Inhibitory effect of polyphyllin VII (PP7) on ROS generation in the differentiated osteoclasts. BMMs cells were pretreated with various concentrations of PP7 for 2 h. Cells were then induced with or without RANKL plus M-CSF to differentiate into osteoclasts. Intracellular ROS was measured using flow cytometry. Panel a Representative plots of ROS measured with flow cytometry. Panel b Comparison of the fluorescence intensity of DCF among cells treated with various concentration of polyphyllin VII (PP7). Vertical axis: fluorescence density; horizontal axis: polyphyllin VII (PP7) concentration (μM). * P < 0.05, as compared with the cells treated with 0 μM of polyphyllin VII

Back to article page

BMC Musculoskeletal Disorders

ISSN: 1471-2474

Contact us